Nifurtimox

Nifurtimox is the first compound that proved effective in human therapy of the South American trypanosomiasis caused by Trypanosoma cruzi. Chemically itidentified as 3-methyl-N-[(5-niro-2-furanyl) methylene]-4-thiomorpholinamine-1, 2-dioxide. Nifurtimox is tripanocidal against both amastigote and tripomasigote form of Trypanosoma cruzi. iteffective against both acute as well as chronic phase of infection. it is prepared by chemical synthesis. itadministerd orally.

Brands
Adult Dose
Dose: 8 to 10 mg/kg
Single Dose: 9 (9)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Dose: 15 to 20 mg/kg
Single Dose: 18 (17.5)
Frequency: 24 hourly
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Nitrofurane. It belongs to Antiparasitic pharmacological group on the basis of mechanism of action. The Molecular Weight of Nifurtimox is 287.30.
Contraindications
Nifurtimox is contraindicated in conditions like Convulsions,Cerebral impairment.
Effects
The severe or irreversible adverse effects of Nifurtimox, which give rise to further complications include Convulsions, Insomnia, Psychosis, Disorientation, Disturbance of equilibrium.Nifurtimox produces potentially life-threatening effects which include Leucopenia. which are responsible for the discontinuation of Nifurtimox therapy.The symptomatic adverse reactions produced by Nifurtimox are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Anorexia, Myalgia, Urticaria, Skin rash, Paresthesias, Neuralgia, Morbiliform, Exanthema, dizziness.
Indications
Nifurtimox is primarily indicated in conditions like Leishmaniasis, Onchoceriasis, Trypanosomiasis.
Interactions
No data regarding the interactions of Nifurtimox was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
The drug should be used with extreme caution in the pregnant or the breast feeding women and children
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