Amoxicillin

Amoxicillin is oral semisynthetic aminopenicillin similar to ampicillin. Amoxicillin is more stable to gastric acids and more bioavailable than other penicillins. It inhibits the 3rd and final stage of bacterial cell wall synthesis by binding to specific penicillin-binding proteins PBPs that are located inside the bacterial cell wall and are responsible for several steps in the synthesis of the cell wall. Chemically Amoxicillin is D-(-)-a-amino-p-hydroxy-benzyl penicillin. Amoxicillin is a broad spectrum antibiotic and has bactericidal activity against many gram positive and gram negative bacteria. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Amoxicillin is important to take the drug for the full time period as prescribed. If you discontinue the drug it may result in ineffective treatment.


Brands
AMOXICILLIN AMOXICILLIN AMOXICILLIN AMOXICILLIN ARPIMOX ARPIMOX ARPIMOX ARPIMOX ARPIMOX CALAMOX CALAMOX CALAMOX CALAMOX CALAMOX CALAMOX CALAMOX CALAMOX CALAMOX CALAMOX SUPRAMOX SUPRAMOX SUPRAMOX SUPRAMOX SUPRAMOX SUPRAMOX SUPRAMOX PRINCIMOX PRINCIMOX PRINCIMOX PRINCIMOX PRINCIMOX PRINCIMOX PRINCIMOX PRINCIMOX FORTECIN FORTECIN FORTECIN FORTECIN FORTECIN FORTECIN FORTECIN FORTECIN FORTECIN ZEEMOX ZEEMOX ZEEMOX ZEEMOX ZEEMOX ZEEMOX ZEEMOX ZEEMOX ZEEMOX ZEEMOX AMOCILLIN AMOCILLIN AMOCILLIN AMOCILLIN AMOCILLIN AMOCILLIN AMOCILLIN AMOCILLIN AMOCILLIN AMOCILLIN AMOXICAP AMOXICAP AMOXICAP AMOXICAP AMOXICAP AMOXICAP AMOXICAP CLAMENTIN CLAMENTIN CLAMENTIN CLAMENTIN CLAMENTIN CIPAMOX CIPAMOX CIPAMOX CIPAMOX CIPAMOX CIPAMOX CIPAMOX FORTE EPOXIL EPOXIL EPOXIL EPOXIL EPOXIL ETHICILLIN ETHICILLIN ETHICILLIN FEDRAXIL FEDRAXIL FEDRAXIL FEDRAXIL FEDRAXIL FEDRAXIL FEDRAXIL FEDRAXIL FEDRAXIL FEDRAXIL FEDRAXIL BACTOXYL BACTOXYL MOXIFIL MOXIFIL MOXIFIL MOXIFIL MOXIFIL MOXIFIL AMOXIL AMOXIL AMOXIL AMOXIL AMOXIL AMOXIL AMOXIL AMOXIL AMOXIL AMOXIL AMOXIL AMOXIL AUGMENTIN AUGMENTIN AUGMENTIN AUGMENTIN AUGMENTIN AUGMENTIN AUGMENTIN AUGMENTIN AUGMENTIN AUGMENTIN AUGMENTIN ULTRA MOX HIZEMOX HIZEMOX HIZEMOX AMOXILLIN AMOXILLIN AMOXILLIN JAXCIL JAXCIL JAXCIL JAXCIL JAXCIL JAXCIL KLOX KLOX KLOX KLOX KLOX KLOX KLOX PEMOXIN PEMOXIN PEMOXIN PEMOXIN PEMOXIN PEMOXIN PEMOXIN PEMOXIN NOVOCLOX NOVOCLOX NOVOMOX NOVOMOX NOVOMOX NOVOMOX NOVOMOX NOVOMOX MAXIL MAXIL MAXIL MAXIL MAXIL MAXIL MAXIL MAXIL CLIMOX CLIMOX CLIMOX MEDIMOX MEDIMOX MEDIMOX MEDIMOX AMOXYCILLIN CLOCIL FORTE M. CLOX M. CLOX OSPAMOX OSPAMOX OSPAMOX OSPAMOX OSPAMOX OSPAMOX OSPAMOX OSPAMOX HIMOXIN HIMOXIN HIMOXIN HIMOXIN ARCOMOX ARCOMOX ARCOMOX ARCOMOX PENBRO PENBRO PENBRO PENBRO PENBRO PENBRO PENBRO PENBRO MOXYPEN MOXYPEN MOXYPEN SEMOCILLIN SEMOCILLIN SEMOCILLIN AXALYN AXALYN AXALYN AXALYN AXALYN WERIMOX WERIMOX WERIMOX WERIMOX EFFIMOX EFFIMOX EFFIMOX EFFIMOX WYMOX WYMOX WYMOX WYMOX WYMOX WYMOX ZOXICILLIN ZOXICILLIN ZOXICILLIN ZOXICILLIN ZOXICILLIN ZOXICILLIN ZOXICILLIN ZOXICILLIN MOXILIUM MOXILIUM MOXILIUM MOXILIUM MOXILIUM BLOMOX BLOMOX ENMOX ENMOX ENMOX ENMOX AMOXYCILLIN AMOXYCILLIN SKYMOX SKYMOX SKYMOX SKYMOX SKYMOX SKYMOX SKYMOX AMOXIPEN AMOXIPEN AMOXIPEN MB-MOX MB-MOX BIFLOCIN BIFLOCIN BIFLOCIN POLYXIL POLYXIL POLYXIL FLOMOXIN FLOMOXIN WISEP WISEP WISEP WISEP STAVOMOX STAVOMOX STAVOMOX STAVOMOX STAVOMOX AMOXICILLIN AMOXICILLIN AMOXICILLIN AMOXICILLIN AMOXICILLIN CLAMOXIN CLAMOXIN CLAMOXIN CLAMOXIN ELMOX ELMOX EXCELLIN EXCELLIN EXCELLIN EXCELLIN GEOMOXIN GEOMOXIN GEOMOXIN GEOMOXIN GEOMOXIN GEOMOXIN WILMOX WILMOX WILMOX WILMOX WILMOX WILMOX WILMOX CILOXIL DELMOX DELMOX DELMOX DELMOX OCEMOX OCEMOX OCEMOX POTENCIN POTENCIN POTENCIN POTENCIN MOXIN MOXIN MOXIN MOXIN MOXIN AMOXASCOT AMOXASCOT AMOXASCOT AMOXASCOT AMOXASCOT AMOXYGEN AMOXYGEN AMOXYGEN AMOXYGEN AMOXYGEN AMOXYGEN FLUCOMOX FLUCOMOX LAVOMOX LAVOMOX LAVOMOX GLOXIL GLOXIL GLOXIL GLOXIL CLAVOPIN CLAVOPIN IMCOMOX IMCOMOX IMCOMOX AMLANIC AMLANIC AMLANIC AMLANIC MEDIOXIL MEDIOXIL MEDIOXIL MEDIOXIL MEDIOXIL MEDIOXIL MEDIOXIL ZEKATAC ZEKATAC ZEKATAC ZEKATAC CLAVUMOX CLAVUMOX POTENTIN STAFICIN STAFICIN STAFICIN STAFICIN TWIN TWIN SULBAMOX INFANTA BLOMOX FORTE ZEEMOX FORTE CLAMENTIN BD COSMOX COSMOX COSMOX TERMIBEX TERMIBEX TERMIBEX TERMIBEX TERMIBEX MAXIL FORTE AMOXYPEN POLYXIL FORTE NAMOXIL NAMOXIL NAMOXIL NAMOXIL NAMOXIL NAMOXIL MENTIN VAROFLOX SULBAMOX SULBAMOX SULBAMOX SULBAMOX ZAMOCLAV ZAMOCLAV ZAMOCLAV ZAMOCLAV ZAMOCLAV ZAMOCLAV ZAMOCLAV ABAC ABAC SEMOCILLIN FORTE AMOX AMOX AMOX AMOX CLA CLA CLA CLA AMOXIDOX AMOXIDOX AMOXIDOX AMOXIDOX SULBARAX SULBARAX SULBARAX AUGMEX AMOXILITE AMOXILITE AMOXILITE AMOXILITE AMOXILITE AMOXILITE AMOXILITE PLUS AMOXILITE PLUS ADAMOX ADAMOX ADAMOX ADAMOX KEMYCLOX KEMYCLOX KEMYCLOX AMOXY KLAVUTIN VULAMOX VULAMOX VULAMOX KMOXILIN KMOXILIN KMOXILIN KMOXILIN KMOXILIN KMOXILIN KMOXILIN KMOXILIN LOMOXY LOMOXY LOMOXY LOMOXY LOMOXY LOMOXY LOMOXY LOMOXY ALMOX ALMOX AMFLOX AMFLOX AUGMICLAVE AUGMICLAVE AUGMICLAVE AUGMICLAVE SYNTICILLIN SYNTICILLIN SYNTICILLIN SYNTICILLIN LOMENT LOMENT LOMENT LOMENT LOMENT MOXSUL MOXSUL AMOXI CLAVE AMOXI CLAVE AMOXI CLAVE AMOXI CLAVE AMOXI CLAVE AMOXI CLAVE AMOXI CLAVE AMOXI CLAVE AMOXI CLAVE MENTIN FORTE OMXICLV OMXICLV OMXICLV OMXICLV OMXICLV ZINIMIN ZINIMIN ZINIMIN CALAMOX DUO CALAMOX DUO AMOLEXIN AMOLEXIN AMOLEXIN AMOLEXIN AUGMICON BACTAMOX PLUS BACTAMOX PLUS BACTAMOX PLUS CO-FLUX CO-FLUX AMOXIMED AMOXIMED AMOXIMED AMOXIMED CEKAMOX ULTREX ULTREX ULTREX ULTREX ULTREX WILMOX CHEWABLE WILMOX CHEWABLE WILMOX FORTE AMOXICILLIN AMOXICILLIN AMOXIPEN PAEDIATRIC AMOXIPEN PAEDIATRIC CLAV CLAV CLAV CLAV FLUMOXIPEN FLUMOXIPEN FLUMOXIPEN GABOXIL GABOXIL GABOXIL GABOXIL MACTONATE MACTONATE MACTONATE RITE RITE RITE RITE RITE AMCLAV AMCLAV AMCLAV AMCLAV AMCLAV AMCLAV AMCLAV AMCLAV AMCLAV AMOCLAV AMOXIGEN AMOXIGEN AMOXIGEN AMOXIGEN MEDIOXIL-F MEDIOXIL-F AUGMENTIN BD AUGMENTIN BD AUGMENTIN BD CO-AMOXI CO-AMOXI CO-AMOXI CO-AMOXI CO-AMOXI CONCIMOX CONCIMOX CONCIMOX CONCIMOX CONCIMOX AMO-CLAV INJECTION AMO-CLAV INJECTION
Adult Dose
Dose: 0.25 to 0.5 g
Single Dose: 0.38 (0.375)
Frequency: 8 hourly
Route: PO,IV,IM
Instructions: Doses vary according to indication. In typhoid fever and Meningitis , 150 mg/Kg/day in adults and 100-150 mg/kg/day in children should be given. Doses greater than 500 mg is given in divided doses.
Neonatal
Dose: 12.5 to 25 mg/kg
Single Dose: 19 (18.75)
Frequency: 6 hourly
Route: Intramuscular
Instructions:
Paedriatic
Dose: 50 to 100 mg/kg
Single Dose: 75 (75)
Frequency: 6 hourly
Route: Intra Muscular
Instructions:
Characteristics
Amoxicillin also known as Amoxycillin. Amoxicillin Trihydrate is the derivative of Amoxicillin. It is of Semi Synthetic origin and belongs to Penicillanic acid. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Penicillin pharmacological group.The Molecular Weight of Amoxicillin is 419.50. Its pKa is 2.4, 7.4, 9.6.
Contraindications
Amoxicillin is contraindicated in conditions like Lymphoma,Glandular fever.
Effects
The severe or irreversible adverse effects of Amoxicillin, which give rise to further complications include Pseudomembranous colitis, Thrombocytopenia, Stevens johnson syndrome, Nephrotic syndrome, Eosinophilia, Leucopenia, Neutropenia, Seizures, Agranulocytosis, Interstitial nephritis, Hemolysis, Platelet dysfunction.Amoxicillin produces potentially life-threatening effects which include Anaphylactic shock. which are responsible for the discontinuation of Amoxicillin therapy.The signs and symptoms that are produced after the acute overdosage of Amoxicillin include Crystalluria, Hemorrhagic cystitis.The symptomatic adverse reactions produced by Amoxicillin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Anorexia, Diarrhea, Fever, Abdominal pain, Maculopapular rash, Rashes, Gastritis, Indigestion, Urticarial skin rash, Pseudomembranous colitis, Elevation of liver enzymes, Nausea and vomiting, Cholestatic Jaundice, Hepatitis, Bullous rash, Arrhythmia.
Indications
Amoxicillin is primarily indicated in conditions like Abscesses, Acute bronchitis, Bacteriuria, Bronchitis, Carbuncles, Cellulitis, Chronic bronchitis, Cystitis, Dental abscess, Dental abscess (short-course), Endocarditis, Furunculosis, Gonorrhoea, Gynecological infections, Haemophilus influenzae infections, Helicobacter pylori eradication, Infected wounds, Inflammatory bowel disease, Lower respiratory tract infections, Meningitis, Metastatic, Metastatic colorectal cancer, Mild to moderate chronic heart failure, Muscle relaxation (short duration) for surgery, Muscle relaxation during intensive care, Muscle relaxation for surgery or intubation, Osteomyelitis, Otitis media, Parathyroid fever, Peritonitis, Pharyngitis, Pneumonia, Puerperal sepsis, Pyelonephritis, Septic abortion, Septicaemia, Sinusitis, Skin infections, Soft tissue infections, Surgical infections, Syphilis, Systemic infections, Tonsillitis, Typhoid, Urinary tract infection.
Interactions
Amoxicillin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementChloramphenicolMethotrexateLarge doses of amoxicillin elevate the serum concentration of methotrexate by competitively inhibiting its renal tubular secretion results in serious hematologic effects.MajorClosely monitor the serum concentration of methotrexate. Dose of methotrexate should be reduce if necessary.Leucovorin rescue should be available.ProbenecidProbenecid increases the mean serum concentration of amoxicillin.RabeprazoleCombined administration consisting of rabeprazole and amoxicillin resulted in increases in plasma concentrations of rabeprazole.Sodium PicosulphateShould not be use concurrently without doctors prescription.Tetracycline (HCl)Warfarin (Na)Concomitant use of amoxicillin and warfarin alters the INR. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Cardiac / Hypertensive Patients, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, Below 40°C. Protect from Moisture. Inj (reconstituted soln) Store at room temperature. Use within 1 hr if kept at room temperature. Oral Susp (reconstituted soln) Store at room temperature or refrigerator. Do not Freeze. Use within 2 weeks if refrigerated and within 1 week if kept at room temperature.
Warnings
Amoxicillin should be used with caution in patients with medical history especially kidney disease, stomach or intestinal problems, blood disorders or drug allergies, especially allergies to other penicillin or cephalosporin antibiotics. Do not use amoxicillin repeatedly or for prolonged period, because use of this medication for prolonged or repeated periods may result in a secondary infection (e.g.oral, bladder or vaginal yeast infection). Use with extreme caution during pregnancy or lactation.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.