Netilmicin (Sulphate)

Netilmicin is a semisynthetic aminoglycoside antibiotic derived from sisomicin, having a range of antibacterial activity similar to that of gentamicin and tobramycin. The sulphate salt of netilmicin, administered intramuscularly and intravenously in the treatment of wide variety of infections caused by susceptible gram-negative organism. Netilmicin (Sulphate) is active alone but also exhibit synergism with β lactam antibiotic. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Netilmicin (Sulphate) is important to take the drug for the full time period as prescribed. Discontinuation of the therapy may result in ineffective treatment.

Brands
N-CRON NETYLIN NETTACIN VEGANET N-CIN
Adult Dose
Dose: 4 to 6 mg/kg
Single Dose: 5 (5)
Frequency: As recommended.
Route: IV,IM, PO
Instructions: As a single dose. Dose may be increased upto 6.5 mg/kg/day in 2 divided doses, depending on the severity and location of infection.
Neonatal
Dose: 2.142 mg/kg
Single Dose: 2.1 (2.142)
Frequency: 12 hourly
Route: Intra Muscular
Instructions: For 3 to 5 minutes
Paedriatic
Dose: 2.142 mg/kg
Single Dose: 2.1 (2.142)
Frequency: 12 hourly
Route: Intra Muscular
Instructions: For 3 to 5 minutes
Characteristics
Netilmicin (Sulphate) also known as Netillin, Netillin, Netillin. . It is of Semi Synthetic origin and belongs to Aminoglycosides. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action. The Molecular Weight of Netilmicin (Sulphate) is 1441.60. Its pKa is 8.1.
Contraindications
Netilmicin (Sulphate)
Effects
The severe or irreversible adverse effects of Netilmicin (Sulphate), which give rise to further complications include Nephrotoxicity, Ototoxicity.Netilmicin (Sulphate) produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Netilmicin (Sulphate) therapy.The symptomatic adverse reactions produced by Netilmicin (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Maculopapular rash, Urticaria, Pain, Phlebitis, Elevated hepatic transaminases.
Indications
Netilmicin (Sulphate) is primarily indicated in conditions like Advanced breast cancer in postmenopausal women, Bacterial infections, Gonorrhoea, Heart failure, Joint infections, Septicaemia, Serious gram -ve infections resistant to gentamicin, Supraventricular arrhythmias (particularly atrial fibrillation), Surgical infections, Urinary tract infection, UTI.
Interactions
Netilmicin (Sulphate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCephradineCisplatinGentamicinRespiratory paralysis and renal dysfunction risk is increased if this combination is used.MajorThis combination should be avoided.Polymyxin B (Sulphate)Vancomycin (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Between 20°C-25°C. Do not Freeze.
Warnings
Netlimicin should be used with caution in patients with history of kidney diseases, vertigo, hearing loss, myasthenia gravis, parkinsonisms. It should be used with caution in patients who are sensitive to aminoglycosides. Keep patients well hydrated to prevent chemical irritation or nephrotoxic reactions. Take appropriate measures in case of secondary infections.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.