Nefopam (HCl)

Nefopam (HCl) is analgesic agent for the treatment of moderate to moderately severe pain. Nefopam (HCl) is chemically and pharmacologically distinct from any other class of analgesic. Chemically Nefopam (HCl) is identified as 3, 4, 5, 6-tetrahydro-5-methyl-1-phenyl-1H-2, 5-benzoxazocine hdrochloride. Nefopam (HCl) is prepared by chemical synthesis and has a unique hetrocyclic structure. Nefopam (HCl) is asdministered orally and parentrally.

Brands
NOVOPAM ACUPAN INZA
Adult Dose
Dose: 30 to 120 mg
Single Dose: 75 (75)
Frequency: 8 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Nefopam (HCl) also known as Benzoxazocine, Benzoxazocine. . It is of Synthetic origin and belongs to Benzoxazocine. It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesic pharmacological group.The Molecular Weight of Nefopam (HCl) is 289.80. Its pKa is 9.2.
Contraindications
Nefopam (HCl) is contraindicated in conditions like Epilepsy,Glucoma,Myocardial infarction,Urinary retention (adynamic bladder),Prostatic hypertrophy,Convulsions.
Effects
The severe or irreversible adverse effects of Nefopam (HCl), which give rise to further complications include Convulsions, Hallucinations, Hallucinations.The signs and symptoms that are produced after the acute overdosage of Nefopam (HCl) include Tachycardia, Convulsions, Hematuria, Hallucinations, Agitation, Coagulopathy, Patch necrosis of GI mucosa, Cerebral edema.The symptomatic adverse reactions produced by Nefopam (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Anorexia, Anxiety, Dry mouth, Dysphonia, Sleep disturbance, SweatingX, Syncope, Euphoria, Dry mouth.
Indications
Nefopam (HCl) is primarily indicated in conditions like Before surgery in women who have anaemia due to uterine fibroids, Pain, and can also be given in adjunctive therapy as an alternative drug of choice in Cancer, Surgery.
Interactions
Nefopam (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinADVICE: Avoid concomitant use of Aspirin with NSAIDs (increased risk of side effects). CodeineDiazepamHalothaneHydroxyzineIndomethacinPentazocinePropiverine HydrochlorideTaking two or more antimuscarinic drugs together can increase their side effects.PropoxypheneRauwolfia ReserpineVORICONAZOLEVoriconazole may increase the serum concentration of nefazodone by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Chromatographic Analysis of Codein, Diazepam & Pentazocine
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store at room temperature, Below 30°C. Do not Freeze. Tab Store Below 30°C.
Warnings
Nefopam should be used with caution in patients with glaucoma, urinary retention, impaired kidney or liver function or in elderly patients.
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