Nadolol

Nadolol is oral, nonselective, beta-adrenergic receptor antagonist similar to propranolol. Chemically Nadolol is identified as (2R, 3S)-5-[ 3-(tert-butylamino)-2-hydroxypropoxy ]-1, 2, 3, 4-tetrahydronaphthalene-2, 3-diol. It does not demonstrate appreciable intrinsic sympathomimetic or membrane-stabilizing activities. Unlike propranolol, it possesses a low degree of lipid solubility and has the longest plasma half-life of all the beta-adrenergic-blocking agents. It was approved by the FDA in December 1989. The actions and uses similar to that of propranolol, but Nadolol is more potent than propranolol. It slows the heart rate and reduces high blood pressure

Brands
CORGARD
Adult Dose
Dose: 40 to 240 mg
Single Dose: 140 (140)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Catecholamine. It belongs to Beta adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Beta Blocker, Nonselective pharmacological group.The Molecular Weight of Nadolol is 309.40. Its pKa is 9.67.
Contraindications
Nadolol is contraindicated in conditions like Cardiogenic shock,Heart block,Cardiac insufficiency,Obstructive airway disease.
Effects
Nadolol produces potentially life-threatening effects which include Bronchospasm, Heart block, Bronchospasm, Heart failure, Asthma. which are responsible for the discontinuation of Nadolol therapy.The symptomatic adverse reactions produced by Nadolol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Alopecia, Insomnia, Confusion, Bradycardia, Dryness of mouth, Depression, Light headedness, Paresthesias, Cardiac insufficiency, Amnesia, Coolness of extremities, Confusion, Alopecia.
Indications
Nadolol is primarily indicated in conditions like Angina, Cardiac arrhythmia, Control of muscarinic side-effects of neostigmine, Hypertension, Hyperthyroidism, Migraine prophylaxis, Myocardial infarction, Thyrotoxicosis, To prevent recurrence of neural tube defect.
Interactions
No data regarding the interactions of Nadolol was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Nadolol should be used with caution in diabetic patients and patients with kidney or liver disease.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.