Nabumetone

Nabumetone is a nonsteroidal anti-inflammatory drug. Chemically Nabumetone is identified as 4-( 6-methoxy-2-naphthalenyl)-2-butanone. Nabumetone is given by mouth in osteoarthritis and rheumatoid arthritis. The drug itself is a relatively weak inhibitor of prostaglandin synthesis, but Nabumetone is metabolized in the liver to a more active compound. May thus cause less gastro-intestinal irritation than some other drugs in this class such as indomethacin, but is still contraindicated if there is a history of peptic ulceration.

Brands
RELIFEX NILTISL
Adult Dose
Dose: 1000 mg
Single Dose: 1000 (1000)
Frequency: 24 hourly
Route: PO
Instructions: At bed time
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Nabumetone also known as Nabumetona, Nabumetona. . It is of Synthetic origin and belongs to Napthyl Butane. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Nabumetone is 228.30. It is weakly alkaline drug.
Contraindications
Nabumetone is contraindicated in conditions like Peptic ulcer.
Effects
The severe or irreversible adverse effects of Nabumetone, which give rise to further complications include Cholestatic jaundice, Complications of GI ulcerations.The symptomatic adverse reactions produced by Nabumetone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Nausea, Diarrhea, Abdominal pain, Increased intracranial pressure.
Indications
Nabumetone is primarily indicated in conditions like Endometrial thinning before intra-uterine surgery, Osteoarthritis, Pain, Pain and inflammation in rheumatoid arthritis, Rheumatoid arthritis, and can also be given in adjunctive therapy as an alternative drug of choice in Ankylosing spondylitis, Soft tissue rheumatism.
Interactions
No data regarding the interactions of Nabumetone was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Nabumetone should be used with caution in patients with any liver or kidney disease, blood disorders, ulcers, heart disease, alcohol use, high blood pressure, eye disease or allergies, especially drug allergies. It should be used with caution when performing tasks requiring alertness. Limit alcohol intake as it may intensify the drowsiness effect of this medication and make stomach or intestines more likely to bleed. Caution is advised when this drug is used in the elderly. This medication should be used during pregnancy or lactation only if clearly needed. Use of this drug in the last 6 months of pregnancy is not recommended.
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