Mupirocin

Mupirocin is antibiotic, previously known as pseudomonic acid.Used as an ointment to treat bacterial skin infections. Mupirocin is active against gram positive bacteria. Mupirocin is rapidly inactivated following oral administration the absorption and systemic levels are undetectable. Mupirocin is used topically. Mupirocin is also used for elimination of certain nasal bacteria as part of an infection control program.

Brands
BACTROBAN BACTROBAN BACTROBAN BACTROBAN MUPICIN BACTODERM BACTODERM BACTODERM BACTODERM MUPIDERM OCIN CREAM MUPIR CARACIN BACTOGEN PIRIN
Adult Dose
Dose: 2%
Single Dose: 2 (2)
Frequency: 8 hourly
Route: Topical
Instructions: Upto 10 days
Neonatal
Dose: 2%
Single Dose: 2 (2)
Frequency: 8 hourly
Route: Topical
Instructions: -
Paedriatic
Dose: 2%
Single Dose: 2 (2)
Frequency: 8 hourly
Route: Topical
Instructions: -
Characteristics
. It is of Semi Synthetic origin and belongs to Pseudomonic Acid. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Dermatological Products pharmacological group.The Molecular Weight of Mupirocin is 500.60. Its pKa is 5.
Contraindications
Mupirocin is contraindicated in conditions like Hypersensitivity,Wounds,Burns.
Effects
The symptomatic adverse reactions produced by Mupirocin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Rashes, Pruritus, Pharyngitis, Itching, Local pain, Cough, Rhinitis, Stinging on application, Cutaneous reaction, Nasal irritation, Burning sensation, Systemic allergic reactions, Dysgeusia.
Indications
Mupirocin is primarily indicated in conditions like Eczema, Folliculitis, Furunculosis, Impetigo, Nasal infection, Skin infections.
Interactions
No data regarding the interactions of Mupirocin was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Oint Store Below 40°C. Do not Freeze. Protect from Sunlight and Moisture.
Warnings
Use mupirocin with caution in patients with kidney disease. It is classified as pregnancy category B. It should be used with caution during pregnancy or lactation.
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