Molsidomine

Molsidomine is a non benzene, hetrocyclic compound used manily for its vasodialator properties. It dilates the blood vessels. Molsidomine is effective in the treatment of angina (chest pain) and in heart failure following myocardial infarction. Molsidomine is prepared by chemical synthesis and not availble in any combination preparations. Molsidomine is administered orally and parentrally. It is a prodrug w/c metabolize to linsidomine.

Brands
Adult Dose
Dose: 0.028 to 0.076 mg/kg
Single Dose: 0.052 (0.052)
Frequency: 8 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Dose: Not indicated in paeds
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Heterocyclic. It belongs to EDRF (NO) agonist pharmacological group on the basis of mechanism of action and also classified in Antianginal Agents and Vasodilators pharmacological group.The Molecular Weight of Molsidomine is 242.20. Its pKa is 3.0.
Contraindications
Molsidomine is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
Molsidomine produces potentially life-threatening effects which include Carcinogenicity. which are responsible for the discontinuation of Molsidomine therapy.The signs and symptoms that are produced after the acute overdosage of Molsidomine include Hypotension.The symptomatic adverse reactions produced by Molsidomine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Anorexia, Facial flushing, Nausea and vomiting, Orthostatic hypotension.
Indications
Molsidomine is primarily indicated in conditions like Angina, Heart failure, and can also be given in adjunctive therapy as an alternative drug of choice in Myocardial infarction.
Interactions
No data regarding the interactions of Molsidomine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
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