Misoprostol

Misoprostol is a synthetic, oral prostaglandin E1 analog and exists in 1:1 mixture of two diastereoisomers. Misoprostol is used for and is commonly believed to be effective for prevention of gastric and duodenal ulcers secondary to use of nonsteroidal antiinflammatory drugs (NSAIDs), although currently Misoprostol is indicated only for the prevention of gastric ulcers. While Misoprostol is approved for use in preventing NSAID-induced gastric ulcers in high-risk patients and it has been shown to be superior than sucralfate for this condition, uncertainty exists regarding the role of it in patients receiving NSAIDs. Independent of NSAID administration, it has been used as a therapeutic agent in the treatment of active duodenal and gastric ulcers, although Misoprostol is slightly less effective than H-2-antagonists. It was approved by the FDA in December 1988.it inhibits basal and nocturnal gastric acid secretion through a direct action on the parietal cell. Parietal cells contain receptors that have high affinity for prostaglandins of the E series. It can inhibit gastric acid secretion secondary to stimulation from food, alcohol, NSAIDs, histamine, pentagastrin, or caffeine, and this effect appears to be more pronounced with increasing doses. HÁ-antagonists, however, appear to be more potent than it in the ability to inhibit gastric acid output, especially at night.

Brands
PROSOTEC PROSOTEC PROART OSTEOTEC OSTEOTEC CO-FENAC MISO MISO MISO MISO PLUS CYTOPAN CYTOPAN MITE MITE MITE MITE MITEK DIMIS DYCLO-M DYCLO-M TECTOR TECTOR TECTOR PLUS ARSOFIN OTAMIFENAC DOLACT EC ISMART ESMART ESMART ARTHROTEC-50 MESOTEC ERWIN ERWIN BREEKY DICLOTOL CYTOTEC ROTEC ROTEC SMASH SMASH 2 ARTHO PLUS ARTHO DISTOL ZIVUS ZIVUS WONDRA WONDRA STMOM STMOM STMOM S.T MOM MISOCLEAR MISOCLEAR CYTOTOL DICTOL FORTE DICTOL FORTE MISOFEN AEROTEC DFENAC DFENAC ARTISAF Misodoc CYOTEC CYOTEC EVERSHAFA BRAVO DPROSTOL ECLOPROST
Adult Dose
Dose: 200 ug
Single Dose: 200 (200)
Frequency: 6 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Methyl Ester. It belongs to PGE-I-agonist pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Misoprostol is 382.50.
Contraindications
Misoprostol
Effects
The symptomatic adverse reactions produced by Misoprostol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Diarrhea, Abdominal pain, Skin rashes, Cramps, Hypotension, Nausea and vomiting, Dysmenorrhea, Hypermenorrhea, Spotting, Skin rashes, dizziness.
Indications
Misoprostol is primarily indicated in conditions like Benign gastric and duodenal ulceration, Haemorrhage, Peptic ulcer, Prophylaxis of NSAID-induced gastric and duodenal ulceration, and can also be given in adjunctive therapy as an alternative drug of choice in Termination of pregnancy.
Interactions
Misoprostol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinDiclofenac (K) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Do not take misoprostol during pregnancy or lactation, because it can cause miscarriages and serious bleeding if taken during pregnancy. Before taking misoprostol, tell the doctor about taking prescription and nonprescription drugs especially antacids, aspirin and arthritis medication.
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