Minoxidil

Chemically Minoxidil is identified as 2, 4-diamino-6-piperidinopyrimidine 3-oxide. Oral it is an antihypertensive agent while topical Minoxidil is used for alopecia. Due to its potency and adverse reactions, oral Minoxidil is used mainly for patients with severe, drug-resistant forms of hypertension. Tolerance to prolonged therapy with oral it does not appear to be a problem. Although the oral dosage form was originally approved in October 1979 for use in hypertension, it was first discovered in 1965. Subsequently, in August 1988, a topical formulation was approved for the treatment of alopecia. It has a direct vasodilatory effect on arterial smooth muscle, causing a reduction in peripheral resistance and blood pressure.

Brands
MINOXIN PLUS MINOXIN REGROW REGROW HAIR MAX PLUS HAIR MAX MINOXY MINOXY PLUS XINODIL REGRO REGRO
Adult Dose
Dose: 5 to 100 mg
Single Dose: 52 (52.5)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose: 0.1 to 2 mg/kg
Single Dose: 1 (1.05)
Frequency: 24 hourly
Route: Oral
Instructions: Gradually increase the Dose
Paedriatic
Dose: 100 to 200 ug/kg
Single Dose: 150 (150)
Frequency: 24 hourly
Route: Oral
Instructions: Gradually increase the Dose
Characteristics
Minoxidil also known as Minoxidilum. . It is of Synthetic origin and belongs to Pyrimidine. It belongs to Potassium Channel (ATP sensitive) opener pharmacological group on the basis of mechanism of action and also classified in Topical Solution pharmacological group.The Molecular Weight of Minoxidil is 209.30. Its pKa is 4.6.
Contraindications
Minoxidil is contraindicated in conditions like Phaeochromocytoma.
Effects
The severe or irreversible adverse effects of Minoxidil, which give rise to further complications include Tachycardia, Stevens johnson syndrome, Stevens johnson syndrome, Fluid retension, Gynacomastia, Oedema, Ascites, Tachycardia.Minoxidil produces potentially life-threatening effects which include Pericardial effusion. which are responsible for the discontinuation of Minoxidil therapy.The signs and symptoms that are produced after the acute overdosage of Minoxidil include Tachycardia.The symptomatic adverse reactions produced by Minoxidil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Palpitation, Flushing, Breast tenderness, Hypertrichosis.
Indications
Minoxidil is primarily indicated in conditions like Alopecia, Duodenal ulceration associated with H. Pylori, Hypertension.
Interactions
Minoxidil is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementClonidine (HCl)DeflazacortNadololNicorandilConcurrent use can cause a drop in blood pressure, therefore you should tel your doctor know if you feel dizzy during concurrent use of these drugs. Propranolol (HCl)Tretinoin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
False +ve Catecholamine measurement test
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Minoxidil should not be used in patients, who have a myocardial infraction with in the proceeding month Patients with renal (kidney) failure & dialysis may require smaller dose.
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