Mianserin

Mianserin was introduced in 1976 as an antidepressant, Mianserin has a novel tetracyclic structure and a pharmacological action that differed from previuos antidepressant drugs. itused to treat depression, nerve pain, insomnia, bed-wetting in children older than six years.


Adult Dose
Dose: 60 to 90 mg
Single Dose: 75 (75)
Frequency: 24 hourly
Route: PO
Instructions: Initial dose 30 mg
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Amines. It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Tetracycylic Antidepressant pharmacological group.The Molecular Weight of Mianserin is 300.80. Its pKa is 7.05.
Contraindications
Mianserin is contraindicated in conditions like Mania.
Effects
The severe or irreversible adverse effects of Mianserin, which give rise to further complications include Hepatic damage, Jaundice, Jaundice, Breast cancer, Polyartheopathy.Mianserin produces potentially life-threatening effects which include Agranulocytosis, Blood dyscrasias, Aplastic Anemia, Anxiety, Aplastic anemia. which are responsible for the discontinuation of Mianserin therapy.The signs and symptoms that are produced after the acute overdosage of Mianserin include Death.The symptomatic adverse reactions produced by Mianserin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Giddiness, Increased appetite.
Indications
Mianserin is primarily indicated in conditions like Anxiety, Depression.
Interactions
Mianserin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholApraclonidine (HCl)Avoid concomitant use.Clonidine (HCl)FosphenytoinPhenytoin (Na)Propranolol (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store at room temperature. Protect from Sunlight.
Warnings
Caution should be done in the patient with bone marrow depression, usually presenting as granulocytopenia or agranulocytosis, has been reporting during treament. If a patient shows fever, sore throat, stomatitis or other signs of infection, treatment should be stopped and a full blood count should be discountinued. Treatment should be discontinued if convulsions or jaundice occurs.
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