Mexiletine

Mexiletine belongs to class IB-antiarrhythmic group of medicines. Mexiletine is a sodium channel blocking agent. Chemically Mexiletine is 1-methyl-2-(2, 6-xylyloxy) ethylamine. Mexiletine is used as an antiarrhythmic agent and resembles lidocaine in its electro-physiological effects in the heart and has the same uses and equal efficacy but is superior in that it may be used in chronic treatment. its primary advantage is oral efficacy and relatively long half-life. its useful actions are primarily limited to ventricular dysrhythmias. It is used to treat arrhythmia within heart or serious irregular heart beat.

Brands
Adult Dose
Dose: 2.857 to 5.714 mg/kg
Single Dose: 4.3 (4.2855)
Frequency: 8 hourly
Route: PO
Instructions: -
Neonatal
Dose: 2.5 to 4 mg/kg
Single Dose: 3.2 (3.25)
Frequency: 8 hourly
Route: Oral
Instructions:
Paedriatic
Dose: 2.5 to 4 mg/kg
Single Dose: 3.2 (3.25)
Frequency: 8 hourly
Route: Oral
Instructions:
Characteristics
Mexiletine (HCl) is the derivative of Mexiletine. It is of Synthetic origin and belongs to Phenoxyaminoketone. It belongs to Na-Channel Antiarrhythmic antagonist pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.The Molecular Weight of Mexiletine is 215.70. Its pKa is 8.4.
Contraindications
Mexiletine is contraindicated in conditions like Cardiogenic shock.
Effects
The severe or irreversible adverse effects of Mexiletine, which give rise to further complications include Convulsions, Ataxia, Fever, Allergic reactions, Jaundice, Jaundice, Leucopenia, Agranulocytosis, Depression, Wheezing, Chest pain, Cough, Psychiatric disorders.Mexiletine produces potentially life-threatening effects which include Bradycardia, Hypotension, Hepatitis. which are responsible for the discontinuation of Mexiletine therapy.The signs and symptoms that are produced after the acute overdosage of Mexiletine include Convulsions, Seizures, fatigue, Unconsciousness, Heart block, Ventricular asystole, Numbness, Irregularities in heart rhythm.The symptomatic adverse reactions produced by Mexiletine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Constipation, Termors, Rashes, Disorientation, Heart burn, Trembling, Oesophageal ulcerations, dizziness.
Indications
Mexiletine is primarily indicated in conditions like Cardiac arrhythmia, Myocardial infarction, Postinfarct arrythmias, Ventricular arrhythmias, Ventricular arrhythmias, especially after myocardial infarction, Wolf-parkinson-white syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Pain.
Interactions
Mexiletine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmiodarone (HCl)Increased risk of ventricular arrhythmia when amiodarone given with Mexiletine (HCl). ADVICE: Avoid concomitant use or only undertaken with caution and appropriate monitoring.CaffeineDisopyramideIpriflavoneOxycodonePhenytoin (Na)Procainamide (HCl)QuinidineRifampicinTheophylline These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Abnormal LFTs
Risks
Drug should not be given to Cardiac / Hypertensive Patients, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Mexiletine should be used with caution in patients with known seizure disorders, hypotension, intraventricular conduction abnormalities, and hepatic impairment (as liver metabolizes it so half-life may increased). Avoid concurrent diet or drug, which alter the urine pH. Do not drive as Mexiletine may cause dizziness.Oral dose should be taken with swallowed with plenty of water.
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