Metyrapone

'Metyrapone is inhibitor of 11b-hydroxylase, an important cytochrome P450 enzyme involved in the biosynthesis of cortisol and alsosterone. Metyrapone is administered orally. Metyrapone is used in the treatment of cushing''s syndrome. Metyrapone is also used in tests of pituitary gland function..'

Brands
Adult Dose
Dose: 14.28 mg/kg
Single Dose: 14 (14.28)
Frequency: 8 hourly
Route: PO
Instructions: -
Neonatal
Dose: 15 mg/kg
Single Dose: 15 (15)
Frequency: 4 hourly
Route: Oral
Instructions: For One Day
Paedriatic
Dose: 15 mg/kg
Single Dose: 15 (15)
Frequency: 4 hourly
Route: Oral
Instructions: 6 divided doses
Characteristics
Metyrapone also known as Metyrapone Tartrate, Metyrapone Tartrate, Metyrapone Tartrate. . It is of Natural origin and belongs to Pyridylalkane. It belongs to Setroid 11-B-hydroxylase inhibitor pharmacological group on the basis of mechanism of action and also classified in Diagnostic Aids pharmacological group.The Molecular Weight of Metyrapone is 226.30.
Contraindications
Metyrapone is contraindicated in conditions like Adrenal insufficiency.
Effects
The severe or irreversible adverse effects of Metyrapone, which give rise to further complications include Alopecia, Bone marrow depression.The signs and symptoms that are produced after the acute overdosage of Metyrapone include Convulsions, Unconsciousness, Cardiac arrest, Extensor spasm of fingers, Glucocorticoid insufficiency.The symptomatic adverse reactions produced by Metyrapone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Abdominal pain, Sedation, Hypotension, Nausea and vomiting, Hypertension, dizziness, Allergic, Hypoadrenalism.
Indications
'Metyrapone is primarily indicated in conditions like Adrenal failure, Cushing''s syndrome, Differential diagnosis of acth-dependent cushing`s syndrome, Edema, Management of cushing`s syndrome, Oedema, Resistant oedema, and can also be given in adjunctive therapy as an alternative drug of choice in Hypersensitivity, Lactation, Porphyria, Pregnancy.'
Interactions
No data regarding the interactions of Metyrapone was found.
Interfrence
ACTH test
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps,tabs Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Metyrapone should be used only if clearly needed during pregnancy. It should be used with caution in patients with any pre-existing thyroid disorder or any allergy or hepatic impairment.
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