Methylphenidate (HCl)

Methylphenidate (HCl) is a centrally acting sympathatomimetic agent.Methylphenidate (HCl) is a central nervous system stimulant. It increases mental alertness. Methylphenidate (HCl) is used in the treatment of narcolepsy. Methylphenidate (HCl) is used as an adjunct therapy to remedial measures (psychological, educational and social) in the managemnt of minimal brain dysfunction.

Brands
METHRIL RITALIN PHENIDA EVIGIL EVIGIL LEADOPHEN FANIDAN FANIDAN RITAL RILEN MADALIN
Adult Dose
Dose: 5 to 20 mg
Single Dose: 12 (12.5)
Frequency: 8 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Dose: 0.2 mg/kg
Single Dose: 0.2 (0.2)
Frequency: 12 hourly
Route: Oral
Instructions: Dose for 5-12 Yrs of Children
Characteristics
. It is of Synthetic origin and belongs to Phenylamide. It belongs to Amine release pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Stimulant pharmacological group.The Molecular Weight of Methylphenidate (HCl) is 269.30. It is weakly acidic drug, 4.07% solution of the drug is isotonic and Its pKa is 8.5.
Contraindications
Methylphenidate (HCl) is contraindicated in conditions like Agitation,Alcohol dependence,Anxiety,Cardiac arrhythmia,Epilepsy,Glucoma,Hypertension,Psychosis,Thyrotoxicosis,Gille de la tourette syndrome,Hypersensitivity,Tension.
Effects
The severe or irreversible adverse effects of Methylphenidate (HCl), which give rise to further complications include Depression, Agitation, Hyperactivity.Methylphenidate (HCl) produces potentially life-threatening effects which include Convulsions, Cardiac arrhythmias. which are responsible for the discontinuation of Methylphenidate (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Methylphenidate (HCl) include Vomiting, Tachycardia, Cardiac arrhythmias, Convulsions, Confusion, Hallucinations, Sweating, Hyperventilation, Tremor, Mydriasis, Delusions, Pallor, Elevation of BP, Hyperreflexia, Respiratory stimulation, Hyperflexia, Cardiac insufficiency, Loss of conciousness, Muscle twitching.The symptomatic adverse reactions produced by Methylphenidate (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Anorexia, Restlessness, Palpitation, Tachycardia, Insomnia, Nervousness, Abdominal pain, Weight loss, nervousness, Nervousness, dizziness.
Indications
Methylphenidate (HCl) is primarily indicated in conditions like Attention deficit disorders, Depression, Narcolepsy, and can also be given in adjunctive therapy as an alternative drug of choice in Apathetic behaviour, Chronic fatigue, Drug-induced lethargy, Psychoneurosis, Stuttering.
Interactions
Methylphenidate (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineChlorpromazine (HCl)Clomipramine (HCl)Desipramine (HCl)Dothiepin (HCl)Doxepin (HCl)Imipramine (HCl)Imipramine (HCl)IsocarboxazidPhenylbutazone Phenytoin (Na)Phenytoin (Na)PrimidoneThiopentone (Na)Trimipramine (Maleate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Test for the urinary measurement of alkaloids and amphetamine
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Perform periodic blood counts, platelets and differential counts during prolong therapy with methylphenidate. Abrupt discontinuation after long-term administration is not recommended. Methylphenidate should be used cautiously in the patient with the history of the emotional instability, alcoholism or the subtance abuse because the potential for abuse is increased.
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