Methylene Blue

Methylene Blue is used in the treatment of cyanide poisoning and methemoglobinemia (a blood disorder). it is also used as a diagnostic agent because of its blue staining properties. itadministered orally and parentrally. It is not available in any combination preparations. Chemicaly itidentified as 3, 7-bis (dimethylamino) phenothiazine-5-ium chloride trihydrate.

Brands
Adult Dose
Dose: 0.928 to 1.857 mg/kg
Single Dose: 1.4 (1.3925)
Frequency: 8 hourly
Route: PO
Instructions: -
Neonatal
Dose: 3 mg/kg
Single Dose: 3 (3)
Frequency: 8 hourly
Route: Oral
Instructions: -
Paedriatic
Dose: 2 mg/kg
Single Dose: 2 (2)
Frequency: 8 hourly
Route: Oral
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Methylthionine. It belongs to Antidotes pharmacological group.The Molecular Weight of Methylene Blue is 373.90. Its pKa is 0-1.
Contraindications
Methylene Blue is contraindicated in conditions like G6pd deficiency,Renal impairment.
Effects
The severe or irreversible adverse effects of Methylene Blue, which give rise to further complications include Anemia, Anemia, Methemoglobinemia, Hyperbilirubinemia, Hemolysis in infants, Necrotic ulcers, Spinal cord necrosis, Paraplegia, Methemoglobinemia, Anemia, Anemia, Haemolytic anemia.Methylene Blue produces potentially life-threatening effects which include Cardiac arrhythmias, Hypotension. which are responsible for the discontinuation of Methylene Blue therapy.The signs and symptoms that are produced after the acute overdosage of Methylene Blue include Nausea, Confusion, Headache, Abdominal pain, Discoloration of urine.The symptomatic adverse reactions produced by Methylene Blue are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Dyspnea, Tachycardia, Tremors, Abdominal pain, Sweating, Confusion, Dysuria, Chest pain, Discoloration of urine, Apprehension, Confusion, dizziness.
Indications
Methylene Blue is primarily indicated in conditions like Drug-induced methemoglobinemia, Gastric reflux, Gastrointestinal fistulae diagnosis, Genetic methemoglobinemia.
Interactions
Methylene Blue is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementVortioxetine increase toxicity of vortioxetinenever use combintion These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Between 15°C-30°C. Protect from Sunlight, Moisture and Heat.
Warnings
Methylene blue should be used with caution in patients with any pre-existing kidney disease, blood disorders (especially G6PD deficiency) or any allergy. This should be used only if clearly needed during pregnancy. Methylene blue should not be used to treat methemoglobinemia associated with the cyanide toxicity.
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