Methionine

Methionine is a naturally occuring amino acid. Chemically Methionine is 2-amino-4-methyl-mercaptobutyric acid. Methionine is essential constituent of diet. May be used as an antidote in severe poisoning due to Paracetamol where Methionine is thought to prevent liver demage by reducing the concentration of toxic metabolite . Natural sources of it include fish, meat, and vegetable proteins. Given orally it causes few side effects, principally nausea. Must not be given more than ten hours after the over dosage as it may then exacerbate liver demage. .

Brands
LITRISON LIVOTONE PILFOOD MULTINA MAX MULTINA MAX MULTINA MAX MULTINA-33 MULTINA-33 MULTINA-33 HEPATOVIT HONEYPLEX KETOSTERIL AMINOLEBAN ORAL AMINOLEBAN MINOLAD AMINOPLASMAL-L10 AMINOPLASMAL AMINOPLASMAL-E5 AMINOPLASMAL-E5 AMINOPLASMAL-E5 AMINOPLASMAL® HEPA TOXINIL NUTRIFLLEX SPECIAL NUTRIFLLEX SPECIAL NUTRIFLEX PLUS NUTRIFLEX PLUS PROMOD AMISOL NEPHROMAC AMINORAINS
Adult Dose
Dose: 2.5 to 10 g
Single Dose: 6.2 (6.25)
Frequency: As recommended.
Route: PO
Instructions: As Required
Neonatal
Dose: 0.05 g/kg
Single Dose: 0.05 (0.05)
Frequency: 4 hourly
Route: Oral
Instructions: -
Paedriatic
Dose: 0.05 g/kg
Single Dose: 0.05 (0.05)
Frequency: 4 hourly
Route: Oral
Instructions: -
Characteristics
Methionine also known as DL-Methionine. . It is of Natural origin and belongs to Amino Acid. It belongs to Dermatological Products and Liver Prot ective pharmacological group.The Molecular Weight of Methionine is 149.20. Its pKa is 2.28, 9.21.
Contraindications
Methionine is contraindicated in conditions like Acidosis,Chronic liver disease,Schizophrenia.
Effects
Methionine produces potentially life-threatening effects which include Encephalopathy. which are responsible for the discontinuation of Methionine therapy.The signs and symptoms that are produced after the acute overdosage of Methionine include Hypotension, Disorientation, Nausea, Vomiting, Fever.The symptomatic adverse reactions produced by Methionine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Irritability, Nausea, Vomiting.
Indications
Methionine is primarily indicated in conditions like Amino acid deficiency, Diaper rash, Incontinence, Paracetamol overdosage, Paracetamol poisoning.
Interactions
Methionine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCharcoal (Activated)Charcoal (Activated) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Protect from Sunlight.
Warnings
Methionine should be used with caution in patients with severe liver diseases. Methionine should not be given to patients with acidosis.
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