Methimazole

Methimazole is antithyroid drug that is employed for the preparation of the hyperthyroid patient for surgery and for the total treatment of hyperthyroidism. Methimazole is the active metabolite of carbimazole and is given by mouth. Chemically Methimazole is 1, 3-dihydro-1-methyl-2H-imidazole-2-thione.

Brands
Adult Dose
Dose: 0.071 to 0.214 mg/kg
Single Dose: 0.14 (0.1425)
Frequency: 24 hourly
Route: PO
Instructions: Maintenance
Neonatal
Paedriatic
Characteristics
Methimazole also known as Thiamazole, Thiamazole. . It is of Natural origin and belongs to Imidazole. It belongs to Thyroid peroxidease inhibitor pharmacological group on the basis of mechanism of action and also classified in Antithyroid pharmacological group.The Molecular Weight of Methimazole is 114.20.
Contraindications
Methimazole is contraindicated in conditions like Bone marrow depression,Destructive hyperthyroidism,Agranulocytosis.
Effects
The severe or irreversible adverse effects of Methimazole, which give rise to further complications include Hepatitis, Aplastic anemia, Vasculitis, Lupus like syndrome, Drug fever, Hypothyroidism, Hypoprothorombinemia.Methimazole produces potentially life-threatening effects which include Agranulocytosis. which are responsible for the discontinuation of Methimazole therapy.The symptomatic adverse reactions produced by Methimazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Nausea, Skin rash, Arthralgia, Hair loss, Edema, Loss of taste.
Indications
Methimazole is primarily indicated in conditions like Hyperthyroidism, Hyperthyroidism of graves disease, Thyrotoxicosis.
Interactions
Methimazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementClozapineBoth drugs act synergistically result in acute granulocytopenia.MajorClosely monitor for granulocytopenia.Prednisolone and Prednisonemethimazole enhance metabolism of prednisolone and prednisone These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Excessive dose of antithyroid should not be used, because it may cause hypothyroidism or goiter. Treatment with methimazole should be discontinued immediately if there is any clinical or lab. evidence of neutropenia. It is not recommended to use high dose during pregnancy or lactation. Before having an emergency treatment or surgery including dental surgery, tell the doctor about the use of the drug.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.