Amiloride (HCl)

Amiloride is a potassium sparing diuretic. Amiloride (HCl) is antihypertensive agent. Chemically Amiloride (HCl) is identified as N-Amidino-3, 5-diamino-6-chloropyrazinecarboxamide hydrochloride. It reduces the amount of water and sodium retained by the body. Amiloride (HCl) is used to restore normal serum potassium levels in patients who develop hypokalemia and in patients who would be exposed to a perticular risk if hypokalemia were to develop. Amiloride (HCl) is mostly used in conjunction with other drugs to lower blood pressure.

Brands
LASORIDE DURIDE DOSURETIC CONSERVE MODURETIC FRUSERIDE FLOWRIDE FRULIMORIDE MOUZIDE TRURIDE
Adult Dose
Dose: 20 to 50 mg
Single Dose: 35 (35)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Amiloride (HCl) also known as Amipramizide. Amiloride is the derivative of Amiloride (HCl). It is of Synthetic origin and belongs to Chloropyrazine. It belongs to Na channel inhibitor (K-Sparing) pharmacological group on the basis of mechanism of action and also classified in Diuretic Combination pharmacological group.The Molecular Weight of Amiloride (HCl) is 371.50. Its pKa is 8.7.
Contraindications
Amiloride (HCl) is contraindicated in conditions like Acute renal failure,Gout,Hyperkalaemia,Diabetic nephropathy.
Effects
The severe or irreversible adverse effects of Amiloride (HCl), which give rise to further complications include Hyperkalemia.The signs and symptoms that are produced after the acute overdosage of Amiloride (HCl) include Dehydration, Electrolyte imbalance.The symptomatic adverse reactions produced by Amiloride (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Weakness, Dizziness, Vertigo, Headache, Nausea, Alopecia, Anorexia, Dyspnea, Insomnia, Tinnitus, Abdominal pain, Skin rashes, Somnolence, Polyuria, Tremor, Cough, Nasal congestion, Paresthesias, Voice disturbance, Polydipsia.
Indications
Amiloride (HCl) is primarily indicated in conditions like Congestive heart failure, Duodenal ulceration, Edema, Hepatic cirrhosis with ascites, Hypertension, Oedema, and can also be given in adjunctive therapy as an alternative drug of choice in Cystic fibrosis, NIDDM.
Interactions
Amiloride (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlbuterolShould not use concurrently without doctors prescription.Canrenoate (K)Carbenoxolone (Na)Carbenoxolone (Na)ChlorpropamideCyclosporin ADigoxinAmiloride may diminish the therapeutic effect of Digoxin. Specifically, the inotropic effects. ModerateMonitor for decreased therapeutic effects of Digoxin if Amiloride is initiated/dose increased, or increased effects if Amiloride is discontinued/dose decreased.Enalapril (Maleate)enalapril can reduce potassium loss with thiazide diuretics (e.g amiloride, spiranolactone, triametrene) may result in hyperkalemiaLithiumRenal clearance of lithium is reduced by amiloride due to oncrease in serum lithium levels which leads to lithium toxicity.MajorThis combination should be avoided or used with extreme caution include reduce dose of lithium.ithium levels should be monitor.Metformin (HCl)Amiloride compete with metformin for renal tubular transport thus decreases excretion of metformin leads risk of lactic acidosis.ModerateMonitor patient glucose level and adjust metformin dose.MoexiprilConcurrent use may increase the blood pressure or heart rate.PerindoprilLikely interaction of AMILORIDE HYDROCHLORIDE increasing the HYPERKALAEMIC effect of Perindopril Erbumine. ModeratePotassium CanrenoatePotassium CitrateSimultaneous administration of these agents can produce severe hyperkalemia.Concurrent use should be avoided.Potassium GlycerophosphateConcurrent use can increase potassium levels in the body.QuinidineQuinidineQuinidine associated prolongation of QRS segment is enhance by amiloride.This combination act synergistically to block soium channel.MajorThiazide like diuretics can be used as an alternative therapy or QRS segment length should be monitor if use this combination.Rutin (Vitamin P)Rutin may have additive effects when used in combination with Amiloride (HCl).SpironolactoneTacrolimusThiamine HCl (Vitamin B1)Amiloride (HCl) have been associated with decreased thiamin levels in the body by increasing urinary excretion and possibly by decreasing absorption and increasing metabolism. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Measurement of serum digoxin levels by immunoassay
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C.
Warnings
Amiloride should be used with caution in patients with diabetes, kidney or liver disease or any drug allergy. Caution must be observed when eating large amounts of food high in potassium such as bananas, baked potatoes, raisins, cooked spinach and other foods. Alcoholic beverages may increase the effects of this drug, causing dizziness or lightheadedness, so limit alcohol intake. Patients should observe caution while driving or performing other activities requiring alertness. Because this drug changes fluid balance, patients may feel dizzy if change from a lying to a standing position too rapidly, avoid this by sitting up a few minutes before rising. Use with caution during pregnancy or lactation.
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