Methacycline (HCl)

Methacycline (HCl) is a tetracycline antibiotic. Tetracyclines are derivative of polycyclic naphthacenecarboxamide. Tetracyclines are broad spectrum antibiotic. They are bacteriostatic and effective against many gram positive and gram negative bacteria. Antibiotics require constant drug level in body for therapeutic effect. This is achieve by taking the drug at regular intervel of time throughout the day and night as prescribed. Methacycline (HCl) is important to take the drug for the full time period as prescribed. If you discontinue the drug, it may result in ineffective treatment. The antimicrobial agents develops during the last 60 years are among the most dramatic examples of the advances of science. The remarkably powerful and specific activity of antimicrobial drug is due to the their selectivity for highly specific targets that are either unique to micro-organism or much more important in them than in humans.

Brands
Adult Dose
Dose: 4.285 mg/kg
Single Dose: 4.3 (4.285)
Frequency: 12 hourly
Route: PO
Instructions: -
Neonatal
Dose: Not use in this age group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: 0.12 to 0.24 mg/kg
Single Dose: 0.18 (0.18)
Frequency: 12 hourly
Route: Oral
Instructions: Dose for over 8 Yrs paeds
Characteristics
Methacycline (HCl) also known as Metacycline. . It is of Semi Synthetic origin and belongs to Tetracycline. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Tetracycline Derivative pharmacological group.The Molecular Weight of Methacycline (HCl) is 478.90. It is strongly acidic drug and Its pKa is 3.1, 7.6, 9.5.
Contraindications
Methacycline (HCl) is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Methacycline (HCl), which give rise to further complications include Azotemia, Hyperphosphatemia, Acidosis.Methacycline (HCl) produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Methacycline (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Methacycline (HCl) include Vomiting, Diarrhea.The symptomatic adverse reactions produced by Methacycline (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Anorexia, Maculopapular rash, Glossitis, Dysphagia, Enterocolitis, Erythematous rash, Photosensitivity reactions, Exfoliative dermatitis, Benign intracranial hypertension, Superinfection.
Indications
Methacycline (HCl) is primarily indicated in conditions like Bacterial infections, Gonorrhoea, Pneumonia, Syphilis.
Interactions
No data regarding the interactions of Methacycline (HCl) was found.
Interfrence
Flase +ve Flourescence in the Hingerty Method for measuring Catecholamines. Flase +ve Urea Level in pre-existing renal impairment
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Cap, Oral soln Store in a well closed container. Protect from Sunlight.
Warnings
It should not be used in case of hypersensitivity to other tetracyclines, photosensitivity, and impaired renal function.
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