Mesna

Mesna is a detoxifying agent. Mesna is used to protect bladder mucosa from the irritant effect of ifosfamide or cyclophosphamide (anticancer drugs), acts by combining with thier toxic metabolite acrolein but does not prevent thier other toxic effects. Chemically Mesna is identified as sodium 2-mercaptoethane sulfonate. It also has mucolytic properties. It also has a mucolytic activity. Mesna is available for oral and intravenous administration.

Brands
UROMITEXAN MESNEX MESNEX MESNEX MESNAL MESNA
Adult Dose
Dose: 1.625 to 1.82 g/sq.metre
Single Dose: 1.7 (1.7225)
Frequency: As recommended.
Route: IV Inf
Instructions: 100-112% by weight of Ifosamide, As Required
Neonatal
Paedriatic
Dose: 240 to 360 mg/sq.meter
Single Dose: 300 (300)
Frequency: 8 hourly
Route: Intra Venous
Instructions: 20%w/w of Ifosfamide Dose
Characteristics
Mesna also known as Sodium 2-Mercapto-Ethanesulfonate. . It is of Synthetic origin and belongs to Mercaptoethane. It belongs to Antidotes pharmacological group.The Molecular Weight of Mesna is 164.20.
Contraindications
Mesna is contraindicated in conditions like Hypersensitivity.
Effects
The signs and symptoms that are produced after the acute overdosage of Mesna include Headache.The symptomatic adverse reactions produced by Mesna are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Diarrhea, Tachycardia, Abdominal pain, Hypotension, Cough, Bronchospasm, Limb pain, Joint pain, Exhaustion, Yellowing of teeth.
Indications
Mesna is primarily indicated in conditions like Cyclophosphamide induced hemorrhagic cystitis, Ifosfamide induced hemorrhagic cystitis, Prostate cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Cancer.
Interactions
No data regarding the interactions of Mesna was found.
Interfrence
False +ve test for Ketone bodies in Urine
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Inj Store at room temperature, Below 30°C. Protect from Sunlight.
Warnings
Mesna should be avoided if possible during pregnancy or lactation. It should be used with caution in patients with any pre-existing illness or any allergy.
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