Megestrol (Acetate)

Megestrol is a sex hormone orally active synthetic derivative of progeterone, actions and effects are similar to that of progesterone. Used to suppress oestrogen-dependent tumours of the breast and the uterus by interferingwith uptake of oestrogen into the tumours. Chemically Megestrol (Acetate) is identified as 17-hydroxy-6-methylpregne-4,6-diene-3, 20-dione acetate. Adverse effects include weight gain, hair loss, deep venous thromboses in the legs.

Brands
MEGACE MEGACE MEDESTROL MEGESTIL PROGACE PROGACE
Adult Dose
Dose: 40 to 320 mg
Single Dose: 180 (180)
Frequency: 6 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: Not indicated in this age group
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Steroid. It belongs to Progesterone agonist pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Progestin pharmacological group.The Molecular Weight of Megestrol (Acetate) is 384.50. Its pKa is not relevant.
Contraindications
Megestrol (Acetate) is contraindicated in conditions like Diabetes mellitus,Dysfunctional uterine bleeding,Vaginal bleeding,Thrombophlebitis.
Effects
The severe or irreversible adverse effects of Megestrol (Acetate), which give rise to further complications include Hypertension, Pulmonary embolism, Heart failure, Deep vein thrombosis.The symptomatic adverse reactions produced by Megestrol (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Alopecia, Urticaria, Weight gain, Edema, Hot flushes, Increased appetite, Carpal tunnel syndrome, Hyperglycemia, Mood changes, Tumor flare.
Indications
Megestrol (Acetate) is primarily indicated in conditions like Breast cancer, Prostatic cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Cancer cachexia, Endometrial cancer, Renal carcinoma.
Interactions
No data regarding the interactions of Megestrol (Acetate) was found.
Interfrence
None well documented
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Susp Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Megestrol should be used with caution in patients with liver disease, depression, incomplete abortion, unusual vaginal bleeding, suspected pregnancy, blood clotting problems and of any allergy. Contraceptive (birth control) measures are recommended for use in men and women while taking this medication. Megestrol is not recommended for use during pregnancy or lactation.
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