Mefenamic Acid

Mefenamic Acid is a NSAID (non steroidal antinflammatory drug). Mefenamic Acid is prepared by chemical synthesis and chemically Mefenamic Acid is N-(2, 3-xylyl) anthranilic acid. Mefenamic Acid is used for its both antinflammatory and antipyretic properties. Mefenamic Acid is given by mouth to treat arthritis, headaches, menstrual cramps, muscle aches, dental pain.


Brands
GARDAN MEFTAN MEFTAN MEFTAN MEFTAC MEFTAC MEFTAC MEFTAC MEFTAC DOLOR DOLOR DOLOR DOLOR DOLOR PONSAC FORTE PONSAC PONSAC PONSAC BOSCHTAN MEDOCID PLAIN MEDOCID PLAIN MEDOCID FORTE MEFNAC MEFNAC MEFNAC MEFNAC MEPON MEPON MEFNA EPOSTAN EPOSTAN EPOSTAN EPOSTAN DOLORAN DOLORAN DOLORAN DOLORAN INFLANIL FORTE MEFENAMIC ACID MEFENAMIC ACID FONSTAL FONSTAL MELLIN MELLIN MEFLIN MEFLIN MEFLIN MEFLIN SONISTAN SONISTAN SONISTAN HASMIC HASMIC KAYPAN KAYPAN KAYPAN FORTE MINISTAL MINISTAL MINISTAL JA-STAN JA-STAN JA-STAN JA-STAN JA-STAN JA-STAN MAFNOL MAFNOL MEFNACIN MEFNACIN MARTAN MARTAN MARTAN AMIC AMIC AMIC MEFENAMIC ACID MEFENAMIC ACID MEFENAMIC ACID MEFENAMIC ACID MEFENAMIC ACID NOVOMIC NOVOMIC NOVOMIC MEFENAMIC ACID ATNAF PONGESIC PONGESIC PONGESIC RESTI DOLOGIN DOLOGIN DOLOGIN DOLOGIN OBSTAN NENGESIC NEOMEF NEOMEF MENAMIC MENAMIC MEFENAMIC ACID MEFENAMIC ACID MEFADIL MEFADIL MEFADIL MEFADIL FORTE FENSTAN FENSTAN FORTE PHONTAN PHONTAN ZOPAN ZOPAN PONSTAN FLASH PONSTAN PONSTAN PONSTAN FORTE PONSTAN FORTE PHARMIC PHARMIC PHARMIC PHARMIC FORTE MEFAD MEFAD MEFAD MAXIMUS TABLET MAXIMUS TABLET MAXIMUS TABLET MAXIMUS TABLET MADOPAR MADOPAR A-PNAMIC A-PNAMIC PROTAN PROTAN ANAPEN FORTE GARDAN FORTE REXAFENAMIC MEFALGIC MEFALGIC MEFALGIC FORTE FENAMIC FORTE FENAMIC FORTE FENAMIC FENAMIC FENAMIC KAMIC KAMIC MEFO-250 MEFO MEFOMIDE MEFOMIDE MEFOMIDE MEFOMIDE MEFENAMIC ACID WILSTAN FORTE WILSTAN WILSTAN WILSTAN MEFACID MEFACID ZEGESIC VIO-MEF FORTE VIO-MEF FORTE VIO-MEF FORTE VIO-MEF VIO-MEF MEFGESIC MEFGESIC MEFGESIC FENGESIC FENGESIC MEFADON DEEMAC FORTE DEEMAC FORTE DEEMAC DEEMAC DEEMAC DEEMAC DELMIC DELMIC DELMIC DELMIC FORTE PANAMAZ FORTE PANAMAZ FORTE PANAMAZ PANAMAZ PANAMAZ MB-STAN MB-STAN MB-STAN FORTE PANAMIC PANAMIC PANAMIC REGOCID FORTE REGOCID REGOCID REGOCID REGOCID REGOCID NIVASTAN NIVASTAN FEBRIN FEBRIN FEBRIN PONSIC FORT PONSIC PONSIC PONSIC PONSIC PONSIC NAMIC FORTE NAMIC ANAPAN FORTE ANAPAN MEFENAMIC ACID MEFENAMIC ACID STAIFAMINE SAPIMIC MEFLON MEFCO FORTE MEFCO FORTE MEFCO FORTE MEFCO MEFENAMIC ACID MEFENAMIC ACID KEMISTAN KEMISTAN MEFMIC MEFMIC MEFMIC DAVIPON MEFNAGEN MEFNAGEN MEDGESIC BEFENAC BEFENAC BEFENAC PONFAB PONFAB PONFAB MEFHEIM MEFESCOT MEFESCOT MEFAIM MEFAIM PRESTAN GLOMAC GLOMAC FYMEF FYMEF FYMEF FLAMAR FLAMAR FLAMAR FORTE MAMIC FORTE MAMIC MAMIC MAMIC REMOSTAN REMOSTAN REMOSTAN AMNIC AMNIC AMNIC AMNIC MEFNAX MEFNAX ACIMEF ACIMEF ACIMEF ACIMEF ALMEF FORT ALMEF UNISTAN UNISTAN SOLACY SOLACY SOLACY AAFIA AAFIA MAFIC WENAMIC WENAMIC SYNGESIC GRAYMAF FORTE HANZEL PAINTON PAINTON PAINTON FORTE MOFSTAN MOFSTAN MOFSTAN MOFSTAN HEFMIC HEFMIC HEFMIC CIMAN CIMAN CIMAN MEFINN MEFINN MEFINN MEFINN LONSTAN LONSTAN AUSTAN AUSTAN AUSTAN AUSTAN FORT GENSTON GENSTON GENSTON GENSTON MEFCID MEFCID UNIMEF KOHIMAX PONS
Adult Dose
Dose: 500 mg
Single Dose: 500 (500)
Frequency: 8 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 25 mg/kg
Single Dose: 25 (25)
Frequency: 8 hourly
Route: Oral
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Anthranilic Acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Mefenamic Acid is 241.30. Its pKa is 4.2.
Contraindications
Mefenamic Acid is contraindicated in conditions like Asthma,Peptic ulcer,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Mefenamic Acid, which give rise to further complications include Diarrhoea, Peripheral edema, Urticaria, Gi bleeding, GI bleeding, Proteinuria, Aplastic anemia, Aplastic anemia, Epidermal necrolysis, Jaundice, Jaundice, Nephrotic syndrome, Interstitial nephritis, Papillary necrosis, Hemolysis, Proctocolitis, Enteritis, Large bowel perforation, Epidermal necrolysis, Platelet dysfunction, Aplastic anemia, GI perforation, Proteinuria, proteinuria, Haemolytic anemia.Mefenamic Acid produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia, Pancytopenia, Leucopenia, Heart failure, Bone marrow hypoplasia, Reversible autoimmune hemolysis. which are responsible for the discontinuation of Mefenamic Acid therapy.The signs and symptoms that are produced after the acute overdosage of Mefenamic Acid include Grand Mal Seizures (epilepsy), Excitation, Depression, Incoordination.The symptomatic adverse reactions produced by Mefenamic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Skin rashes, Maculopapular rash, Hematuria, Elevation of liver enzymes, Anemia, Azotemia, Bullous rash, Skin rashes, dizziness.
Indications
Mefenamic Acid is primarily indicated in conditions like Dysmenorrhoea, Fever, fever, Inflammation, Juvenile chronic arthritis, Menorrhagia, Migraine, Musculoskeletal disorders, Osteoarthritis, Pain, Post-operative pain, Post-partum pain, Rheumatoid arthritis, Symptomatic relief of GI-disorders, Toothache, Traumatic pain.
Interactions
Mefenamic Acid is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementSulfapyridineConcurrent use with sulfapyridine may increase the potential for toxic side effectsTorasemideMefanamic acid, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Mefanamic acid is initiated, discontinued or dose changed.VORICONAZOLEMefanamic acid may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects Vortioxetineeither increases effects of the other by anticoagulationmonitor closely These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
False +ve test for the presence of Bile in Urine
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Caps Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Mefenamic acid should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension and other conditions predisposing to fluid retention. It should be used with extra care in the presence of existing uncontrolled infection. Perform periodic auditory function test during chronic therapy. Discontinue drug if skin reaction occurs.
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