Medroxyprogesterone (Acetate)

Medroxyprogesterone (Acetate) is oral and parenteral synthetic progestin a (sex hormone). Medroxyprogesterone (Acetate) is 15 times more potent than progesterone. Can be used for the treatment of amenorrhea, abnormal uterine bleeding, endometriosis secondary to hormonal imbalances, and endometrial and renal cell carcinomas. The IM injection is a sustained-release (i.e., "depo") product available in 2 dosage strengths: one for use as a contraceptive and the other for the treatment of endometrial and renal cell carcinoma.it may be useful as respiratory stimulants in certain pulmonary disorders such as chronic obstructive pulmonary disease (COPD). it was approved by the FDA in 1959. The primary contraceptive effect of progestins involves the suppression of the midcycle surge of LH. The exact mechanism of action, however, is unknown. At the cellular level, progestins diffuse freely into target cells and bind to the progesterone receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge, thereby preventing follicular maturation and ovulation. Overall, progestin-only contraceptives prevent ovulation in 70-80% of cycles.

Brands
MEDROXY DEPO DEPO PROVERA SAHELI MEDROSTERONA MEDROSTERONA CICLOTAL CICLOTAL MEGESTRON ROXYPROG DEPO FAMILA MEDROXYPROGESTERONE CLIMANOR CLIMANOR
Adult Dose
Dose: 150 mg
Single Dose: 150 (150)
Frequency: As recommended.
Route: IM
Instructions: (Depot Inj.) During first 5 days of cycle or in first 5 weeks postpartum. repeat at 3 months intervals.
Neonatal
Dose: Not applicable for this age group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: Not applicable for this age group
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
Medroxyprogesterone (Acetate) also known as Methylacetylprogestron, Methylacetylprogestron. . It is of Synthetic origin and belongs to Steroid. It belongs to Progesterone agonist pharmacological group on the basis of mechanism of action and also classified in Sex Hormones and Contraceptive Hormonal pharmacological group.The Molecular Weight of Medroxyprogesterone (Acetate) is 386.50.
Contraindications
Medroxyprogesterone (Acetate) is contraindicated in conditions like Hepatic dysfunction,Hypersensitivity,Abnormal uterine bleeding,Phlebitis,Hematuria.
Effects
The severe or irreversible adverse effects of Medroxyprogesterone (Acetate), which give rise to further complications include Urticaria, Impotence, Jaundice, Increased blood pressure, Thrombophlebitis, Hyperglycemia, Hypertension, Depression, Pulmonary embolism, Retinal thrombosis, Myalgia, Decreased libido, Breakthrough bleeding, Thromboembolism.Medroxyprogesterone (Acetate) produces potentially life-threatening effects which include Anaphylactoid reactions. which are responsible for the discontinuation of Medroxyprogesterone (Acetate) therapy.The symptomatic adverse reactions produced by Medroxyprogesterone (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Alopecia, Diarrhea, Anxiety, Insomnia, Abdominal pain, Termors, Weight LossX, SweatingX, Weight gain, Elevation of liver enzymes, Muscle cramps, Fluid retention, Acne, Hirsutism, Amenorrhea, Anovulation, Vaginal spotting, Cushing syndrome, Dysmenorrhea, Reaction at injection site, Cervicitis, Appetite stimulation.
Indications
Medroxyprogesterone (Acetate) is primarily indicated in conditions like Adjunctive treatment of endometrial carcinoma, Adjunctive treatment of renal carcinoma, Breast cancer, Contraception, Dysfunctional uterine bleeding, Endometrial cancer, Endometriosis, Mild to moderate endometriosis, Progestogenic opposition of oestrogen hrt, Secondary amenorrhoea, Uterine bleeding, and can also be given in adjunctive therapy as an alternative drug of choice in Pelvic congestion, Renal carcinoma.
Interactions
Medroxyprogesterone (Acetate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAminoglutethimideAminoglutethimide reduces the plasma concentration of Medroxyprogesterone (Acetate)CyclophosphamideFluorouracilMethotrexateTamoxifen (Citrate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Gonadotrophin Test Pregnanediol Test Oestrogen Test Glucose Test Progesterone Test Testosterone Test Cortisol Test Liver Function Test Metyrapone Test
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 15°C-30°C.
Warnings
Medroxyprogesterone acetate should be used with caution in patients with any allergy (especially drug allergies), abnormal vaginal bleeding, liver, kidney or heart disease, missed abortion, blood clots, seizures, migraine, asthma, depression or diabetes. Limit alcohol, as this may increase side effects of this drug. It is not recommended to take it in early pregnancy.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.