Mecillinam

Mecillinam is a derivative of amidinopenicillanic acid. Unlike benzylpenicillin and related antibiotics, Mecillinam is active against many Gram -ve bacteria in perticular Enterobacteriaceae including Escherichia coli, Enterobacter, Klebsiella, Salmonella and Shigella spp.; Mecillinam is less active against Neisseria spp. and Haemophilus influenzae. It interferes with the synthesis of the bacterial cell wall by binding with a different penicillin-binding protein from benzylpenicillin. Mecillinam is inactivated by beta-lactamases, but is more stable than ampicillin.

Brands
Adult Dose
Dose: 0.071 to 0.214 mg/kg
Single Dose: 0.14 (0.1425)
Frequency: 6 hourly
Route: IM
Instructions: -
Neonatal
Dose: 5 to 15 mg/kg
Single Dose: 10 (10)
Frequency: 8 hourly
Route: Intra Muscular
Instructions: -
Paedriatic
Dose: 5 to 15 mg/kg
Single Dose: 10 (10)
Frequency: 8 hourly
Route: Intra Muscular
Instructions: -
Characteristics
. It is of Semi Synthetic origin and belongs to Penicillin. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Mecillinam is 325.40. Its pKa is 3.4, 8.9.
Contraindications
Mecillinam is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The symptomatic adverse reactions produced by Mecillinam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Vaginitis, Thrombophlebitis.
Indications
Mecillinam is primarily indicated in conditions like Bacterial infections, Enteric fever, UTI.
Interactions
No data regarding the interactions of Mecillinam was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 25°C. Protect from Moisture.
Warnings
It should not be given in case of hypersensitivity to penicillins.
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