Mebeverine

Mebeverine (HCl) is antispasmodic agent with direct action on the smooth muscle of the gastrointestinal tract. It relieves the abdominal pain and cramps. It was first registered in 1965. Mebeverine (HCl) is administered orally.


Adult Dose
Dose: 135 to 150 mg
Single Dose: 140 (142.5)
Frequency: 8 hourly
Route: PO
Instructions: 20 mins before meals,
Neonatal
Paedriatic
Dose: 25 mg
Single Dose: 25 (25)
Frequency: As recommended.
Route: For 3-4 years
Instructions:
Characteristics
Mebeverine (HCl) is the derivative of Mebeverine. It is of Synthetic origin. It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Gastrointestinal Anticholinergics/Antispasmodics and Antispasmodic Agent pharmacological group.The Molecular Weight of Mebeverine is 466.00. Its pKa is 8.1.
Contraindications
Mebeverine
Effects
The symptomatic adverse reactions produced by Mebeverine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Anorexia, Insomnia, Allergic reactions, Erythematous rash, Angioedema, Gastrointestinal disturbances, Erythematous rash, dizziness.
Indications
Mebeverine is primarily indicated in conditions like Adjunct in GI-disorders, Chronic irritable colon, Gastrointestinal spasm, GIT spasm, Irritable bowel syndrome, Mucous colitis, Spastic colon, Spastic constipation.
Interactions
No data regarding the interactions of Mebeverine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C.
Warnings
Pregnancy and breast-feeding, also avoid in porphyria.Should be used with care in marked hepatic or renal impairment & heart block.
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