Mebendazole

Mebendazole is a broad spectrum anthelmintic or antiparasitic agent. It was developed in 1972. Chemically Mebendazole is identified as (5-benzoyl-1H-benzimidazol-2-y) carbamic acidmethyl ester. Mebendazole is effective in intestinal worm infections such as pinworm, round worm and hook worm. Mebendazole is administered orally.


Adult Dose
Dose: 100 mg
Single Dose: 100 (100)
Frequency: 12 hourly
Route: PO
Instructions: For 3 consecutive days.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Benzimidazol. It belongs to Fumarate reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anthelmintics pharmacological group.The Molecular Weight of Mebendazole is 295.30.
Contraindications
Mebendazole
Effects
The severe or irreversible adverse effects of Mebendazole, which give rise to further complications include Alopecia, Thrombocytopenia, Bone marrow depression.Mebendazole produces potentially life-threatening effects which include Leukopenia. which are responsible for the discontinuation of Mebendazole therapy.The symptomatic adverse reactions produced by Mebendazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Diarrhea, Pyrexia, Abdominal colic, dizziness.
Indications
Mebendazole is primarily indicated in conditions like Ascariasis, Capillaria infection, Enterobiasis, Gastric acid reduction (surgical procedures), Giardiasis, Guinea worm infection, Hook worm infection, Hydatid disease, Onchoceriasis, Pin worm infection, Prostate cancer, Roundworm infection, Tapeworm infection, Thread-worm, Thread-worm infection, Trichinosis, Whip worm infection, Whipworm infection.
Interactions
Mebendazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepineFosphenytoinHuman InsulinInsulin GlulisineInsulin LisproLevamisolePhenytoin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
None well documented
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Susp Store in a well closed container, Below 40°C.
Warnings
Mebendazole should be used with caution in patients with liver disease, anemia or reaction to this medication previously. It should be used with caution during pregnancy or lactation.
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