Loperamide (HCl)

Loperamide (HCl) is antidiarrheal agent. Loperamide (HCl) is chemically related to haloperidol, acting diractly on the intestinal wall o inhibit paristalsis. It acts mora rapidly and is longer acting than diphenoxylate and cogeine. Loperamide (HCl) is also effective to reduce the amount of discharge from ileostomies. Loperamide (HCl) is prepared by chemical synthesis. Loperamide (HCl) is administered orally.


Adult Dose
Dose: 4 to 16 mg
Single Dose: 10 (10)
Frequency: 24 hourly
Route: PO
Instructions: Followed by 2mg/dose after each stool upto max dose of 16mg/day.
Neonatal
Paedriatic
Dose: 0.05 mg/kg
Single Dose: 0.05 (0.05)
Frequency: 6 hourly
Route: Oral
Instructions: -
Characteristics
. It is of Synthetic origin and belongs to diphenylbutyramide. It belongs to Antidiarrhoeals pharmacological group.The Molecular Weight of Loperamide (HCl) is 513.50. Its pKa is 8.7.
Contraindications
Loperamide (HCl) is contraindicated in conditions like Acute dysentry.
Effects
The signs and symptoms that are produced after the acute overdosage of Loperamide (HCl) include Constipation, Somnolence, Bradypnea, Muscular hypertonia, Neurological symptoms, Ileus.The symptomatic adverse reactions produced by Loperamide (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Fatigue, Nausea, Vomiting, Skin reactions, Abdominal cramps, Urticaria, dizziness.
Indications
Loperamide (HCl) is primarily indicated in conditions like Acute diarrhoea, Chronic diarrhoea in adults, Control of agitated states in elderly without confusion, Diarrhoea, The pain of bowel colic in palliative care.
Interactions
Loperamide (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCholestyramineColestipol (HCl)Desmopressin (Acetate)Plasma concentration of oral Desmopressin increased by Loperamide.Loperamide increase fastrointestinal absorption of desmopressin. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
None well documented
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Liq Protect from Sunlight and Heat. Tab Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Discontinue Loperamide if clinical improvement is not observed in 48hrs.in case of acute diarrhea. Monitor patients with hepatic (liver) dysfunction for sign of CNS toxicity. Loperamide should not be used in diarrhea caused by poisoning, pseudomembranous colitis and infection with enterotoxin-producing bacteria.
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