Lisuride

Lisuride is a dopamine receptor agonist. Lisuride is semisynthetic ergot derivative belonging to the 8a-aminoergoline group. Lisuride is effective in the treatment of parkinsons disease especially in the latter stages of disease when the treatment fails.It is reported to have serotonergic activity and has been used in disorders associated with hyperprolactinaemia. Lisuride is not available in any combination preprations. Lisuride is administered orally.

Brands
DOPERGIN
Adult Dose
Dose: 0.002 mg/ kg
Single Dose: 0.002 (0.002)
Frequency: As recommended.
Route: IV
Instructions: As Required
Neonatal
Paedriatic
Characteristics
Lisuride also known as Methylergol Carbamide Maleate, Methylergol Carbamide Maleate, Methylergol Carbamide Maleate. . It is of Semi Synthetic origin and belongs to Ergot Alkaloid. It belongs to D2 agonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Hormones pharmacological group.The Molecular Weight of Lisuride is 454.50. Its pKa is 7.
Contraindications
Lisuride is contraindicated in conditions like Peripheral vascular disease,Pituitary disease,Coronary heart disease.
Effects
The severe or irreversible adverse effects of Lisuride, which give rise to further complications include Confusion, Drowsiness, Delirium, Memory disturbance, Visual hallucination, Frequent & vivid dreams, Vivid dreams.The signs and symptoms that are produced after the acute overdosage of Lisuride include Hallucinations, Exanthemia, Satyriasis.The symptomatic adverse reactions produced by Lisuride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Vomiting, Abdominal pain, Itching, Weight gain.
Indications
'Lisuride is primarily indicated in conditions like Cushing''s syndrome, Hyperprolactinaemia, Migraine prophylaxis, Neuroleptic malignant syndrome, Parkinsonism, Parkinson''s disease, and can also be given in adjunctive therapy as an alternative drug of choice in Acromegaly, Galactorrhoea.'
Interactions
No data regarding the interactions of Lisuride was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab
Warnings
Liver disease may alter the response to drugs in several ways. Prescribing should be kept to a minimum in all patients with severe liver disease, especially if jaundice, ascites, or evidence of encephalopathy present. Consider dose reduction in renal failure to avoid possibility of toxicity, increased sensitivity, and side effects.
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