Liothyronine (Na)

Liothyronine (Na) is a thyroid hormone, probably the active hormone to which thyroxine is converted. Given by mouth or injection it has effect similar to thyroxine but more rapid and short lived. Used when rapid effect is required such as in myxoedema coma.Used with care if there is aevidence of cardiovascular disease as it may precipitate cardiac failure.

Brands
Adult Dose
Dose: 0.25 to 0.714 ug/kg
Single Dose: 0.48 (0.482)
Frequency: 12 hourly
Route: IV
Instructions: -
Neonatal
Dose: 0.625 ug/kg
Single Dose: 0.62 (0.625)
Frequency: 24 hourly
Route: Oral
Instructions: Initial, Gradually increase to maintenance dose
Paedriatic
Dose: 0.625 ug/kg
Single Dose: 0.62 (0.625)
Frequency: 24 hourly
Route: Oral
Instructions: Initial
Characteristics
. It is of Synthetic origin and belongs to Tyrosine. It belongs to Thyroxine agonsit pharmacological group on the basis of mechanism of action and also classified in Thyroid Hormone pharmacological group.The Molecular Weight of Liothyronine (Na) is 650.00. Its pKa is 2.2, 8.4, 10.1.
Contraindications
Liothyronine (Na) is contraindicated in conditions like Adrenal insufficiency,Angina,Cardiac failure.
Effects
The severe or irreversible adverse effects of Liothyronine (Na), which give rise to further complications include Tachycardia, Cardiac arrhythmias, Hyperthyroidism, Agitation.The signs and symptoms that are produced after the acute overdosage of Liothyronine (Na) include Thyrotoxicosis.The symptomatic adverse reactions produced by Liothyronine (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Palpitation, Insomnia, Nervousness, Weight LossX, Menstrual irregularity, Heat intolerance.
Indications
Liothyronine (Na) is primarily indicated in conditions like Diagnostic test for thyroid cancer differentiation, Hypothyroid coma, Hypothyroidism, Hypothyroidism (myxoedema), Myxedema coma.
Interactions
No data regarding the interactions of Liothyronine (Na) was found.
Interfrence
False result of thyroxine level Supress Radioiodine uptake in normal individual
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Liothyronine should be used with caution in patients with any heart problems, diabetes, adrenal gland problems or of any allergies, including drug allergies. Avoid using thyroid drugs for weight control. Current information shows that this drug may be used during pregnancy when clearly needed. It should be used with caution during lactation.
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