Lindane

Lindane is a gamma isomer of hexachlorocyclohexane. It was commonly called gamma benzene hexachloride which was a misnomer because benzene ring is not present in this compound. Lindane is a powerful parasiticide with a rapid action against the majority of external parasites, including Pediculus humanus var. capitis. Lindane is used topically on skin or hair for lice and scabies. Lindane is only available for topical administeration.


Adult Dose
Dose: 1%
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Topical
Instructions: As Required
Neonatal
Dose: 1%
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Topical
Instructions: As Required
Paedriatic
Dose: 1%
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Topical
Instructions: As Required
Characteristics
Lindane also known as gamma benzene, gamma benzene, gamma benzene. . It is of Synthetic origin and belongs to Benzene. It belongs to Dermatological Products and Antiparasitic pharmacological group.The Molecular Weight of Lindane is 290.80. Its pKa is not ionizable.
Contraindications
Lindane is contraindicated in conditions like Hypersensitivity,Seizures,Skin inflammation.
Effects
The severe or irreversible adverse effects of Lindane, which give rise to further complications include Insomnia, Paresthesia, Giddiness.Lindane produces potentially life-threatening effects which include Seizures, Aplastic Anemia, Aplastic anemia. which are responsible for the discontinuation of Lindane therapy.The signs and symptoms that are produced after the acute overdosage of Lindane include Vomiting, Convulsions, Collapse, Restlessness, Muscular spasm, Loss of equilibrium.The symptomatic adverse reactions produced by Lindane are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Restlessness, Abdominal cramps, Confusion, Cough, Skin irritation, Contact dermatitis, Psoriasis, Confusion, dizziness, Contact dermatitis.
Indications
Lindane is primarily indicated in conditions like Pediculosis, Scabies.
Interactions
No data regarding the interactions of Lindane was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Lotion, Cream, Shampoo Store in a well closed container, Below 40°C. Do not Freeze.
Warnings
Lindane should not be used in patients with seizure disorders, have open wounds or sores or are allergic to lindane. Elderly persons may be more sensitive to the effects of this medication and a dose reduction may be required. Pregnant women should not be treated more than twice during the pregnancy. Lidane should not be used in neonates, infants 2 years old and younger because of the possibility of high systemic absorption. Children 10 years old and younger also should be treated cautiously with lindane because of an increased potential for toxicity.
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