Lincomycin (HCl)

Lincomycin is an antibiotic produced by a variant of Streptomyces lincolnesis. Lincomycin (HCl) is effective against gram positive bacteria. Lincomycin (HCl) is administered intramuscularly and intravenously. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular intervals of time throughout the day and night as prescribed. Lincomycin (HCl) is important to take the drug for the full time period as prescribed. If you discontinue the therapy it may result in ineffective treatment.


Adult Dose
Dose: 600 mg
Single Dose: 600 (600)
Frequency: 24 hourly
Route: IM
Instructions: Frequency may be increased upto twice daily if needed.
Neonatal
Dose: 10 mg/kg
Single Dose: 10 (10)
Frequency: As recommended.
Route: Intra Muscular
Instructions: Once in 24 Hours
Paedriatic
Dose: 10 to 0 mg/kg
Single Dose: 5 (5)
Frequency: As recommended.
Route: Intra Muscular
Instructions: In divided doses.
Characteristics
Lincomycin is the derivative of Lincomycin (HCl). It is of Semi Synthetic origin and belongs to Glactoride. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Lincomycin (HCl) is 461.00. It is weakly acidic drug, 6.60% solution of the drug is isotonic and Its pKa is 7.6.
Contraindications
Lincomycin (HCl) is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Lincomycin (HCl), which give rise to further complications include Pseudomembranous colitis, Thrombocytopenia, Angioneurotic edema, Serum sickness, Granulocytopenia, Leucopenia, Neutropenia, Erythema multiforme, Glossitis, Elevated transaminases, Apnea, Vaginitis.Lincomycin (HCl) produces potentially life-threatening effects which include Syncope, Hypotension, Anaphylaxis. which are responsible for the discontinuation of Lincomycin (HCl) therapy.The symptomatic adverse reactions produced by Lincomycin (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Fever, Tinnitus, Skin rashes, Urticaria, VertigoX, StomatitisX, Esophagitis, Perianal irritation, Rectal irritation, Vaginal irritation.
Indications
Lincomycin (HCl) is primarily indicated in conditions like Anaerobic infections, Chronic middle ear infection, Colitis, Impetigo, Osteomyelitis, Pneumonia.
Interactions
Lincomycin (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcuronium (Cl)Atracurium (Besylate)BamifyllineClindamycinDistigmine (Br)ErythromycinKaolinRocuronium (Br) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Liver Function Test (LFT) Periodic blood count
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 30°C. Do not Freeze. Protect from Sunlight and Moisture.
Warnings
Lincomycin should be used with caution in patients with kidney or liver disease. Take appropriate measures in case of secondary infections. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).
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