Lignocaine is a sodium channel blocking agent, used as a local anesthetic and antiarrhythmic agent. It stabilizes nerve cell membranes to prevent impulse conduction. Used topically or by injection for local anaesthesia in minor operations.Intravenous injection or infusion used to treat abnormal heart rhythms. Excessive doses also block motor impulses and normal cardiac conduction. It has a low incidence of toxicity and a high degree of effeciveness in arrhythmias. Lignocaine is one of the least cardiotoxic drug of the currently used sodium channel blocker.
Effects
The severe or irreversible adverse effects of Lignocaine, which give rise to further complications include Allergy, Hypotension, Bronchospasm, Coma, Seizures, Hypertension, Tissue necrosis, Angina, Sinus bradycardia, Respiratory depression, Blurred vision, Tremors, Malignant hyperthermia, Neonatal depression, Cardiovascular depression.Lignocaine produces potentially life-threatening effects which include Respiratory depression, Bradycardia, Convulsions, Hypersensitivity, Cardiac Arrest, CNS toxicity, Medullary depression, Tonic & clonic convulsion. which are responsible for the discontinuation of Lignocaine therapy.The signs and symptoms that are produced after the acute overdosage of Lignocaine include Bradycardia, Hypotension, Death, Apnea, Seizures, Respiratory arrest, Cardiovascular collapse, Decrease cardiac output.The symptomatic adverse reactions produced by Lignocaine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Nausea, Vomiting, Anxiety, Restlessness, Palpitation, Nervousness, Tinnitus, Abdominal pain, Confusion, Tremor, Nystagmus, Abdominal discomfort, Twitching, nervousness.