Levonorgestrel

Levonorgestrel is a sex hormone with actions, uses similar to progesterone.. its (-) isomer is used clinically. Chemically Levonorgestrel is identified as 13-ethyl-17-hydroxy-18, 19-dinorpregn-4-en-20-yn-3-one. Levonorgestrel is pricipally used in combination with synthetic estrogen etinyl estadiol for contraception. It can also be used topically through an intrauterine contraceptive device.


Adult Dose
Dose: 0.75 mg
Single Dose: 0.75 (0.75)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Hormone. It belongs to Progesterone agonist pharmacological group on the basis of mechanism of action and also classified in Sex Hormones and Contraceptive Oral pharmacological group.The Molecular Weight of Levonorgestrel is 312.40.
Contraindications
Levonorgestrel is contraindicated in conditions like Migraine,Breast cancer,Hepatic disease,Circulatory system disease,Genital tract bleeding,Endometrial cancer,Lipid metabolism disorder.
Effects
The severe or irreversible adverse effects of Levonorgestrel, which give rise to further complications include Malignant hypertension.Levonorgestrel produces potentially life-threatening effects which include Venous thromboembolism, Ischemic heart disease, Cerebrovascular disease, Venous thromboembolism, Cerebrovascular disease. which are responsible for the discontinuation of Levonorgestrel therapy.The symptomatic adverse reactions produced by Levonorgestrel are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Nausea, Vomiting, Anxiety, Weight gain, Breast tension, Depressive moods, Changes in libido, Menstrual irregularity, Abdominal discomfort, Uterine bleeding, dizziness, changes in libido.
Indications
Levonorgestrel is primarily indicated in conditions like Contraception, Hormone replacement therapy, Menstruation disorders, Nausea and vomiting (chemotherapy induced), prevention.
Interactions
Levonorgestrel is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAscorbic AcidCaffeineCo-AmoxiclavPhenobarbitonePhenytoin (Na)PrimidoneRifampicinTegaserodTegaserod decreased Levonorgestrel plasma concentrations by less than 10% in a clinical study with a low-dose triphasic oral contraceptive (n=45). The mechanism is unknown. There were no changes in ethinyl estradiol concentrations or in contraceptive efficacy. No action is necessary.Minor These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Serum Tests for Adrenal Corticosteroids Urine Tests for 17-Ketosteroids and 17-OH Corticosteroids and Aldosterone Thyopac Method for Measurement of T3
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Levonorgestrel should not be used during pregnancy or lactation. It should be used with caution in patients with any pre-existing liver disease, diabetes, seizure disorder, kidney disease, heart trouble, visual disorders, asthma or a history of depression, migraines, blood clots, miscarriage, breast cancer or any allergy.
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