SINEMET NEUDOPA DUODOPA FORT SINEDOPA BIDOP DOPASEL OBSONERV OBSONERV OBSONERV OBSONERV OBSONERV OBSONERV OBSONERV OBSONERV OBSONERV OBSONERV OBSONERV OBSONERV SINEMET EXTRA SINEMET EXTRA SINEMET EXTRA APTIDOPA

Dose: 100 mg
Single Dose: 100 (100)
Frequency: 8 hourly
Route: PO
Instructions: Initial, With carbidopa 25 mg, increase gradually as required .

Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:

Levodopa also known as L-dopa, L-dopa. . It is of Natural origin and belongs to Phenyl Alanine. It belongs to Dopamine agonist pharmacological group on the basis of mechanism of action and also classified in Antiparkinson Agents pharmacological group.The Molecular Weight of Levodopa is 197.20. Its pKa is 2.3, 8.7,9.7, 13.4.

Levodopa is contraindicated in conditions like Psychosis,Narrow-angle glaucoma,Skin lesions.

The severe or irreversible adverse effects of Levodopa, which give rise to further complications include Hallucinations, Hallucinations, Delirium, Dyskinesias, Mental disturbances, Cardiac irregularities, Bradyphrenia.Levodopa produces potentially life-threatening effects which include Cardiac arrhythmias, Postural hypotension, Anginal pain, Postural hypotension. which are responsible for the discontinuation of Levodopa therapy.The signs and symptoms that are produced after the acute overdosage of Levodopa include Hypotension, Nausea, Vomiting, Cardiac arrhythmias, Confusion.The symptomatic adverse reactions produced by Levodopa are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Vomiting, Anorexia, Diarrhea, Palpitation, Constipation, Abdominal pain, GI upset, Elevated alkaline phosphatase, Elevated hepatic transaminases, Faintness, Discoloration of urine, GI bleeding, dizziness, faintness.

'Levodopa is primarily indicated in conditions like Dopa-responsive dystonia, Parkinsonism, Parkinson''s disease, Parkinson''s disease (but not drug-induced extrapyramidal symptoms), Restless legs syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Glucoma.'

Levodopa is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlprazolamAmitriptyline (HCl)Levodopa serum concentration is reduced by amitriptyline due to slow gastric emptying and increase gastric degradation.Patient monitor for altered safety and efficacy.Benserazide (HCl)Biperiden (HCl)Bupropion (HCl)Increased risk of side effects when Bupropion given with Levodopa.CabergolineClidinium (Br)Clonidine (HCl)Clonidine decreases the efficacy of levodopa.ModerateClosely monitor for the signs of akinesia and increased rigidity.DacarbazineDiazepamDetoriation of Parkinsonism occurs in patients when take diazepamDiazoxideEnhanced hypootensive effect when Diazoxide given with Levodopa.DroperidolDrotaverineEphedrineFlupenthixol (HCl and Decanoate)Flupenthixol (HCl and Decanoate)FurazolidoneLevodopa precipitate severe hypertensive reactions when treated with furazolidone by availibility of catecholamine and increased synthesis of dopamine.MajorInsted of levodopa carbidopa has been prescribed and atleast 14 days gap should be given during other administration.Gonadorelin (HCl)GuanethidineGuanethidineHaloperidolHalothaneHalothaneImipramine (HCl)Iron SaltsIsocarboxazidIsoproterenolLisurideMethyldopaLevodopa increases the antihypertensive effect of methyldopa and thus increase the risk of hypotension.MinorBlood pressure should be monitor regularly.Metoclopramide (HCl)Metoclopramide antagonize the pharmacological effect of levodopa. Central nervous system depressent effect of both of these agents synergistically increased.ModeratePatient should be alerted to drowsiness.MidazolamMoclobemideMultiple VitaminsConcurrent use may decrease the absorption of Levodopa.Separate your doses of Levodopa as far as possible from doses of multi vitamins.OrphenadrinePapaverine (HCl)Papaverine (HCl)PenicillaminePerphenazinePhenylalaninePhenylalanine may reduce the effectiveness of levodopa.Phenytoin (Na)ProcarbazineLevodopa exacerbate the hypertensive crises associated with procarbazine by enhancing peripheral availability of catecholamine and by decreasing degradation and increasing synthesis of dopamine.MajorCombination should be considered contraindicated. Coadministration of carbidopa prevents hypertensive crises by inhibiting peripheral conversion of levodopa to dopamine. There should b gap of at least 14 days between stopping therapy with procarbazine and initiating treatment with levodopa.ProchlorperazinePyridoxinePyridoxine enhances decarboxylqqation of Levodopa and reduces its effectiveness.QuazepamTherapeutic effects may be diminished in some patients following the addition of a benzodiazepine.Quinagolide (HCl)Rauwolfia ReserpineReserpineRopinirole (HCl)Thioridazine (HCl)Tranylcypromine (Sulphate)Trifluoperazine (HCl)ZiprasidoneZiprasidone antagonizes the effect of Levodopa and Dopamine agonists. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Serum tests for bilirubin, catecholamines, creatinine, glucose and uric acid Urine tests for aminoacids, creatinine, creatinine clearance, oestrogens, glucose & Uric Acid Urine tests for Ketone, Vanillylmandelic acid, 5-OH Indoleacetic Acid

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab, Caps Store Below 40°C. Protect from Sunlight and Moisture.

It should be used with caution in patients with glaucoma, history of skin cancer, breathing problems, heart, kidney, liver, endocrine disease, ulcers, depression or blood disorders. It should be used during pregnancy only if clearly needed. Do not take this during lactation.