Lactulose

Lactulose is a synthetic derivative of lactose, chemically Lactulose is identified as 4-0-β-D-Galactopyranosyl-D-fructofuranose. Lactulose is a disaccharide sugar containing one molecule of galactose and one molecule of fructose. It is used in the treatment of hepatic encephalopathy and as a osmotic laxative. Clinical response in the treatment of hepatic encephalopathy is about equal to that of neomycin. It was approved by the FDA in 1976.


Adult Dose
Dose: 15 to 30 ml
Single Dose: 22 (22.5)
Frequency: As recommended.
Route: PO
Instructions: As Required
Neonatal
Dose: 209.3 mg/kg
Single Dose: 210 (209.3)
Frequency: 12 hourly
Route: Oral
Instructions:
Paedriatic
Dose: 2.5 to 0 ml
Single Dose: 1.2 (1.25)
Frequency: As recommended.
Route: As required according to age.
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Disaccharide Carbohydrate. It belongs to Antimicrobial Agent pharmacological group.The Molecular Weight of Lactulose is 342.30.
Contraindications
Lactulose is contraindicated in conditions like Galactosaemia,GI obstruction.
Effects
The severe or irreversible adverse effects of Lactulose, which give rise to further complications include Hypokalemia, Hyponatremia, Hyponatremia.Lactulose produces potentially life-threatening effects which include Dehydration. which are responsible for the discontinuation of Lactulose therapy.The symptomatic adverse reactions produced by Lactulose are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Diarrhea, Abdominal pain, Nausea and vomiting, Bloating, Eructation.
Indications
Lactulose is primarily indicated in conditions like Constipation, Hepatic encephalopathy.
Interactions
Lactulose is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementMesalazine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Oral Syrup, Rectal Soln Store in a well closed container, Below 20°C. Protect from Sunlight.
Warnings
Lactulose should be use with caution in diabetic patients. Avoid use in patients with intestinal obstruction, in patients on low galactose diet. It is relatively contraindicated prior to surgery, especially if the procedure requires the electroquatery during colonoscopy and procto-scopy. The drug should only be used during pregnancy and lactation when clearly needed.
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