Ketotifen (Fumarate)

Ketotifen (Fumarate) is potent antihistaminic agent which exhibit strong H1 receptor blocking activity. Ketotifen (Fumarate) is prepared synthetically. Ketotifen (Fumarate) is effective in the preventive management for asthma and in the treatment of allergic conditions such as rhinitis and conjunctivitis. Ketotifen (Fumarate) is administered orally.


Adult Dose
Dose: 1 to 2 mg
Single Dose: 1.5 (1.5)
Frequency: 12 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 0.03%
Single Dose: 0.025 (0.025)
Frequency: As recommended.
Route: Opthalmic
Instructions: From 3 year of age.
Characteristics
. It is of Synthetic origin and belongs to Piperidylbenzocycloheptane. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action and also classified in Antihistamine, H1 Blocker, Opthalmic pharmacological group.The Molecular Weight of Ketotifen (Fumarate) is 425.50. Its pKa is 8.43.
Contraindications
Ketotifen (Fumarate) is contraindicated in conditions like Hypersensitivity,Impaired alertness.
Effects
The signs and symptoms that are produced after the acute overdosage of Ketotifen (Fumarate) include Tachycardia, Convulsions, Drowsiness, Confusion, Hyperactive reflexes, Cyanosis, Hyperexcitability, Dyspnea.The symptomatic adverse reactions produced by Ketotifen (Fumarate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Dry mouth, Lethargy, Weight gain, Dry mouth, dizziness.
Indications
Ketotifen (Fumarate) is primarily indicated in conditions like Allergic conjunctivitis, Allergic rhinitis, Prophylaxis of asthma, and can also be given in adjunctive therapy as an alternative drug of choice in Dysfunctional uterine bleeding, menorrhagia.
Interactions
No data regarding the interactions of Ketotifen (Fumarate) was found.
Interfrence
Elevated liver enzymes
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Caps, Elixir, Eye Drops Store Below 25°C.
Warnings
Ketotifen is limited for topical ophthalmic use only. Not to treat contact lens-related irritation. After ketotifen use, soft contact lense wearers should wait atleast 10 minutes before putting their lenses in. Do not wear contact lenses if eyes are red. Do not contaminate dropper tip or solution when placing drops in eyes. Safety and efficacy not established in patients
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