PROFENID PROFENID PROFENID PROFENID GABRILEN DOWFEN KETOTOP FASTUM ETOPAR ETOPAR KETONEL KETONEL KETOFLEX MOBIFEN STAYFEN STAYFEN STAYFEN PROKETO UTOFEN UTOFEN INFLO-KET INFLO-KET PRIFEN KETOPRIME SILOFEN PREFEN KETODAN ALPROF ALKET PROTIFEN EC PROTIFEN EC KETOMAX TICON TICON

Dose: 100 mg
Single Dose: 100 (100)
Frequency: 24 hourly
Route: Intra Rectal
Instructions: At bed time

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

. It is of Synthetic origin and belongs to Propionic Acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Ketoprofen is 254.30. Its pKa is 4.55.

Ketoprofen is contraindicated in conditions like Peptic ulcer,Bronchospasm,Rhinitis,Renal insufficiency.

The severe or irreversible adverse effects of Ketoprofen, which give rise to further complications include Reduced GFR (glomerular filtration rate), Acute interstitial nephritis, Platelet dysfunction.Ketoprofen produces potentially life-threatening effects which include Gastrointestinal hemorrhage. which are responsible for the discontinuation of Ketoprofen therapy.The signs and symptoms that are produced after the acute overdosage of Ketoprofen include Hypotension, Vomiting, Bronchospasm, Drowsiness, Abdominal pain, GI hemorrhage.The symptomatic adverse reactions produced by Ketoprofen are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Nausea, Vomiting, Diarrhea, Constipation, Photosensitivity, Skin rash, Dyspepsia, GI upset, Bullous rash, dyspepsia, Gastric pain.

Ketoprofen is primarily indicated in conditions like Ankylosing spondylitis, Bursitis, Gastro-oesophageal reflux disease, Gout, Lumbago, Management of cushing`s syndrome, Musculoskeletal disorders, Osteoarthritis, Pain, Rheumatic diseases, Rheumatoid arthritis, Synovitis, Tendinitis, Tenosynovitis, and can also be given in adjunctive therapy as an alternative drug of choice in Dental pain, Dysmenorrhoea, Fever, fever, Infections, Migraine, Orthopedic manipulations.

Ketoprofen is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCyclosporin AFrusemide or FurosemideKetoprofen may diminish the diuretic effect of Furosemide.ModerateMonitor for decreased therapeutic effects of Furosemide if a nonsteroidal anti-inflammatory agent (NSAID) is initiated/dose increased, or increased effects if an NSAID is discontinued/dose decreased. Consider using an NSAID that holds a lesser potential for interacting with Furosemide (eg, diflunisal, flurbiprofen, ketoprofen, and ketorolac). Patients with heart failure may be more sensitive to alterations in fluid balance, in which case consideration should be given to avoiding the concomitant use of NSAIDs and Furosemide. Cirrhotic patients with ascites may also be at increased risk.LithiumMethotrexateExcretion of methotrexate is reduced by ketoprofen thus increase toxicity.MajorLow dose of methotrexate should be used and closely monitor thesign and symptoms of bone marrow suppression and nephrotoxicity.Probenecid These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Liver Function Test (LFT) Complete blood cell count

Drug should not be given to patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Caps Store Below 15°C. Protect from Sunlight and Moisture.

Ketoprofen should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory (hearing) function test during chronic therapy. Discontinue drug if skin reaction occurs. Ketoprofen is not recommended in the patient who have experienced a severe Aspirin hypersensitivity reactions. IM injection should be administered cautiouly to patient receiving ketoprofen.