Isradipine

Isradipine is a calcium-channel blocking agent of the dihydropyridine class similar to nifedipine, amlodipine, and felodipine. On a miligram-per-miligram basis, Isradipine is the mostpotent drug ?? of this class of drug.it was approved by the FDA in December 1990 for the treatment of hypertension. The mechanism of action is similar to other calcium-channel antagonists, acts by inhibiting the influx of extracellular calcium across the cell membrane of myocardial and vascular smooth muscle. The serum calcium levels remain unchanged. it increases myocardial oxygen supply (secondary to coronary vasodilation) and also decreases myocardial oxygen demand (secondary to decreased afterload and lack of an increase in heart rate). These effects seem to best explain the benefit of it and other dihydropyridines in the treatment of angina. It also causes vasodilation in coronary, skeletal, and cerebral vasculature.

Brands
DYNACIRC
Adult Dose
Dose: 5 to 20 mg
Single Dose: 12 (12.5)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
Isradipine also known as Isradipinum, Isradipinum. . It is of Synthetic origin and belongs to Dihydro Pyridine. It belongs to Calcium L-channel antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Isradipine is 371.40.
Contraindications
Isradipine is contraindicated in conditions like Heart failure,Aortic stenosis,Sinus node disease.
Effects
The severe or irreversible adverse effects of Isradipine, which give rise to further complications include Sinus tachycardia, Hypotension, Hypotension, Angina, Bradyarrhythmias.Isradipine produces potentially life-threatening effects which include Heart failure. which are responsible for the discontinuation of Isradipine therapy.The symptomatic adverse reactions produced by Isradipine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Dyspnea, Palpitation, Tachycardia, Skin rashes, Peripheral edema, Pruritus, Malaise, Weight gain, Flushing, Polyuria, Abdominal discomfort, Gingival hyperplasia, Skin rashes, dizziness.
Indications
Isradipine is primarily indicated in conditions like Angina, Hypertension, Recent myocardial infarction.
Interactions
Isradipine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmobarbitalBarbiturates reduces hypotensive effects of Calcium-channel blockers (e.g Isradipine).MajorCimetidine (HCl)Phenytoin (Na)Propranolol (HCl)RifampicinVORICONAZOLEVoriconazole may increase the serum concentration of isradipine by decreasing its metabolism. . Consider alternate therapy or monitor for changes in the therapeutic and adverse effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps, Tab Store Below 15°C. Protect from Sunlight and Moisture.
Warnings
Isradipine should be used only if clearly needed during pregnancy. It should be used with caution in patients with pre-existing heart disease, history heart arrhythmias, liver disease, kidney disease or blood disorders. Acautious dosage regimen is recommended for pateints with hepatic dysfunction, chronic heart failure,& elderly.
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