Isoxsuprine

Isoxsuprine is a vasodilator which also stimulates beta-adrenergic receptors. It causes direct relaxation of vascular smooth muscle and its vasodilating action is greater on the artries supplying skeletal muscle than on those supplying skin. It also produces positive inotropic and chronotropic effect. It has been used to arrest premature labour but drugs with a more selective action on beta-2 receptors such as Ritodrine are now generally preferred.

Brands
Adult Dose
Dose: 0.071 to 0.142 mg/kg
Single Dose: 0.11 (0.1065)
Frequency: 3 hourly
Route: IM
Instructions: For 1 Day, then 4-6 hourly for further 2 days
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Adrenaline. It belongs to Beta adrenergic agonist and alpha antagonist pharmacological group on the basis of mechanism of action and also classified in Calcium Channel Blocker and Vasodilators pharmacological group.The Molecular Weight of Isoxsuprine is 337.80. Its pKa is 8.0, 9.8.
Contraindications
Isoxsuprine is contraindicated in conditions like Anaemia,Heart disease,Hypersensitivity,Arterial hemorrhage,Postpartum,Premature detachment of placenta.
Effects
The severe or irreversible adverse effects of Isoxsuprine, which give rise to further complications include Rashes, Allergic reactions, Fetal Tachycardia.The signs and symptoms that are produced after the acute overdosage of Isoxsuprine include Nausea, Fainting, Light headedness, Weakness.The symptomatic adverse reactions produced by Isoxsuprine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Tachycardia, Irregular heart beat, Rashes, Hypotension, Nausea and vomiting, Chest pain, Flushed skin, Pulmonary edema, dizziness.
Indications
Isoxsuprine is primarily indicated in conditions like Arteriosclerosis, Cerebrovascular disease, Premature labour.
Interactions
No data regarding the interactions of Isoxsuprine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight, Moisture and Heat.
Warnings
Isoxsuprine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any blood disorders, bleeding episodes or allergies. Cautions should be taken when driving because Isoxsuprine may cause dizziness. Rise slowly from a sitting or lying position to avoid falling.
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