Dose: 0.143 mg/kg
Single Dose: 0.14 (0.143)
Frequency: As recommended.
Route: IV
Instructions: Initially for Once

Dose: 100 to 500 mg/kg/hour
Single Dose: 300 (300)
Frequency: As recommended.
Route: IV-Inf
Instructions: It can be given for 3-6 hours and ultrasound assessment to moniter effect before considering a second cause of treatment.

Dose: 0.75 mg/kg
Single Dose: 0.75 (0.75)
Frequency: As recommended.
Route: Intra Venous
Instructions: As Required

Alteplase also known as rt-PA, rt-PA. . It is of Natural origin and belongs to Polypeptide. It belongs to Plasminogen Activator pharmacological group on the basis of mechanism of action and also classified in Thrombolytic Agent pharmacological group.The Molecular Weight of Alteplase is 65000.00.

Alteplase is contraindicated in conditions like Peptic ulcer,Recent surgery or trauma,Susceptibility to internal bleeding,Menstruation.

The severe or irreversible adverse effects of Alteplase, which give rise to further complications include Urinary tract bleeding, Gingival tissue bleeding.Alteplase produces potentially life-threatening effects which include Hemorrhage, Hemorrhage. which are responsible for the discontinuation of Alteplase therapy.The signs and symptoms that are produced after the acute overdosage of Alteplase include Bleeding.The symptomatic adverse reactions produced by Alteplase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Hypotension, Hypersensitivity reactions.

Alteplase is primarily indicated in conditions like Acute ischaemic stroke, Myocardial infarction, Peripheral arterial thrombosis, Peripheral venousthrombosis, Pulmonary embolism, Stroke.

Alteplase is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinIncreased risk of severe bleeding in case of concomitant use.ModerateCarefully monitor signs of bleeding.Heparin (Na) and Heparin (Cl)Sodium NitroprussideWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Measurement of plasma fibrinogen Other Coagulation Tests

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Protect from Sunlight.

Alteplase should be used with caution in patients with major surgry, organ biopsy or trauma within the past 10 days, cardiovascular disease, pregnancy, diabetic retinopathy. It should be used with extreme caution in conditions in which bleeding could be hazardous or difficult to control due to its location. If anaphylactic reaction occur during therapy, discontinue the infusion and manage the conditions accordingly. It is not recommended for patients over 80 years.