ROACCUTANE ROACCUTANE ISOTREXIN COSMIN ISOTIN ISO A ISONAS ISONEX ISONEX ISONEX ISONEX ARYNOIN ARYNOIN PLUS ISOTREX ISOZAM ISOZAM VISOREX ISOMERA ACNOTIN ACNOTIN ROACADVAN VERION ISO-BAN PLUS ISOWAN–T SONION SONION SONION SONION ACNEWIN ACNEWIN ACNOREN BEFAST ISO-A ISO-A ISO-A ISOLEX ISOTOP ISOTOP ORATRAXIN ISOTROL ACCUNATE ACCUTANE ACNETRAC ACNETRAC ACNETRAC ACNO ACNO ACNO ACNO ACNO ACNOGEN ACNOGEN ACNOGEN AKNEFIN COSMUN ESOTEK ISODERM ISODERM ISOFACE ISOFACE ISOLIT ISOLIT ISOMED ISOTONE ISOTRI ISTEROL OLEX RECUTANE RECUTE RECUTE RECUTE RECUTE TRESTON TRETIDERM TRETOCIN TREZO TREZO ORANATE ORATANE ORATANE ORIVER ORIVER FREAC FREAC ACCURE ISOFACE TABLET ISOFACE TABLET RESOFT SORETIN

Dose: 35 to 70 mg
Single Dose: 52 (52.5)
Frequency: 24 hourly
Route: PO
Instructions:

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Instructions: Not recommended in this age group

Dose: Doses not established for this age group
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. It is of Synthetic origin and belongs to Retinoid. It belongs to Dermatological Products and Retinoic Acid Derivative pharmacological group.The Molecular Weight of Isotretinoin is 300.40.

Isotretinoin is contraindicated in conditions like Hypersensitivity.

The severe or irreversible adverse effects of Isotretinoin, which give rise to further complications include Thrombocytopenia, Hepatitis, Myalgia, Hypercholesterolemia, Hypercholesterolemia.Isotretinoin produces potentially life-threatening effects which include Depression. which are responsible for the discontinuation of Isotretinoin therapy.The symptomatic adverse reactions produced by Isotretinoin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Alopecia, Abdominal pain, Blurred vision, Arthralgia, Erythematous rash, Cheilitis, Conjunctivitis, Nasal bleeding, Photophobia, Skin sepsis, Desquamation, Facial dermatitis, Epistaxis, Paronychia, Blepharoconjunctivitis, Alopecia, Erythematous rash, Pruritis, Skin fragility, Hearing impairment, Impaired night vision.

Isotretinoin is primarily indicated in conditions like Gram negative folliculitis, Keratiniztion disorders, Mild acne in patients with dysmorphohobia, Rosacea, Severe acne.

Isotretinoin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepineResorcinolConcurrent use with resorcinol may cause a cumulative irritant or drying effect, especially with the application of peeling, desquamating, or abrasive agents, resulting in excessive irritation of the skinRetinol (Vitamin A)Retinol (Vitamin A)Sodium ThiosulphateThe concomitant use of isotretinoin with topical Sodium Thiosulphate may additively increase skin irritation. ModerateConcurrent use should generally be avoided.Tetracycline (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Liver Function Test (LFT) Raised creatine phosphokinase

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Caps Store Below 15°C. Protect from Sunlight and Moisture.

Isotretinoin should be used with caution in patients with medical history, including diabetes, family history of high blood fats (triglycerides), depression or any allergy (including drugs e.g. Tetracyclines). Do not donate blood while taking isotretinoin and for at least one month after stop taking it. Avoid exposure to the sun and sunlamps use a sunscreen and wear protective clothing when exposed to direct sunlight. Isotretinoin can affect night vision. Be cautious when driving or operating any machinery after dark. Avoid the use of alcohol while taking this. It should not be used during pregnancy or lactation. Do not apply isotretinoin gel to your lips, mouth and mucous membrane or in the angle of your nose.