ISODAY ISOKET ISOKET ISDIN ISOBID ISOCORD ISOCORD TINIDIL ISORNIT FLO ISORDIL ISORDIL DI CARD ISONIT ISONIT MAYADIL ISOKET RTD CARDIOWEL ISOLIVE ISOLIVE SORBID SORBID SORBID CARSODIL MONOSOR MONOSOR MANTAN MONORID MONORID ISOBID STREIGHT

Dose: 20 to 40 mg
Single Dose: 30 (30)
Frequency: 12 hourly
Route: PO,Sublingual
Instructions:

Dose: 20 kg
Single Dose: 20 (20)
Frequency: As recommended.
Route:
Instructions:

Isosorbide (Dinitrate) also known as Sorbide Nitrate, Sorbide Nitrate. . It is of Synthetic origin and belongs to Nitrates. It belongs to EDRF (NO) agonist pharmacological group on the basis of mechanism of action and also classified in Antianginal Agents and Vasodilators pharmacological group.The Molecular Weight of Isosorbide (Dinitrate) is 236.10.

Isosorbide (Dinitrate) is contraindicated in conditions like Hypovolaemia,Myocardial infarction,Cardiac temponade,Raised intracranial pressure,Low cardiac output,Obstructive hypertrophic cardiomyopathy.

The severe or irreversible adverse effects of Isosorbide (Dinitrate), which give rise to further complications include Hypotension, Restlessness, Hypotension, Syncope, Collapse, Decreased cardiac output, Paradoxical bradycardia, Pallor.The signs and symptoms that are produced after the acute overdosage of Isosorbide (Dinitrate) include Hypotension, Flushing, Tachycardia, Confusion, Palpitations, Headache, Syncope, Neurologic deficit, Increased intracranial pressure.The symptomatic adverse reactions produced by Isosorbide (Dinitrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Palpitation, Tachycardia, Urinary incontinence, Fecal incontinence, Orthostatic hypotension.

'Isosorbide (Dinitrate) is primarily indicated in conditions like Angina, Chronic heart failure, Fluid and electrolyte loss in diarrhoea, Left ventricular failure, Long-term treatment of healed reflux oesophagitis, Moderate to severe reflux oesophagitis, Prinzmetal''s angina, Prophylaxis and treatment of angina, Prophylaxis of angina, Prophylaxis of stress ulceration, Treatment of angina, Treatment of angina and left ventricular failure, Unstable angina, and can also be given in adjunctive therapy as an alternative drug of choice in Congestive heart failure.'

Isosorbide (Dinitrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCarbamazepineCarbamazepine may increase the metabolism of Isosorbide(Dinitrate). ModerateConsider an alternative drug to avoid therapeutic failure of Isosorbide(Dinitrate).Some combinations are specifically contraindicated by manufacturers. Suggested dosage adjustments are also offered by some manufacturers. Please review applicable package inserts. Monitor for decreased effects of Isosorbide(Dinitrate) if Carbamazepine is initiated/dose increased, and increased effects if Carbamazepine is discontinued/dose decreased.Cimetidine (HCl)Cimetidine(HCl) may decrease the metabolism of Isosorbide(Dinitrate). ModerateMonitor for increased effects of Isosorbide (Dinitrate) if Cimetidine (HCl) is initiated/dose increased, and decreased effects if Cimetidine (HCl) is discontinued/dose decreased.ClarithromycinClarithromycin may decrease the metabolism of Isosorbide(Dinitrate). ModerateConsider an alternative drug in order to avoid toxicity of Isosorbide(Dinitrate). Some combinations are specifically contraindicated by manufacturers. Suggested dosage adjustments are also offered by some manufacturers. Please review applicable package inserts. Monitor for increased effects of Isosorbide(Dinitrate) if Clarithromycin is initiated/dose increased, and decreased effects if Clarithromycin is discontinued/dose decreased.Dihydroergotamine (Mesylate)DisopyramidePhenytoin (Na)Phenytoin may increase the metabolism of Isosorbide(Dinitrate). ModerateConsider an alternative drug in order to avoid therapeutic failure of Isosorbide(Dinitrate). Some combinations are specifically contraindicated by manufacturers. Suggested dosage adjustments are also offered by some manufacturers. Please review applicable package inserts. Monitor for decreased effects of Isosorbide(Dinitrate) if Phenytoin is initiated/dose increased, and increased effects if Phenytoin is discontinued/dose decreased.QuinineQuinine may enhance the hypotensive effect of Isosorbide. ModerateMonitor for excessive decreases in blood pressure if Quinine is used concomitant with other herbs or drugs possessing a similar potential. VORICONAZOLEVoriconazole may increase the serum concentration of isosorbide dinitrate by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

False Decrease in Serum Cholestrole when measured by Zlotkis-Zak color reaction technique Increase urinary conc. of catecholamines.

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store in a well closed container, Below 40°C. Protect from Moisture and Heat.

Excessive use of isosorbide dinitrate may cause headache, so reduce the dose and use analgesics (painkiller). In terminating treatment of angina, gradually reduced the dose in order to avoid withdrawal reactions. Extended-release isosorbide (dinitrate) should be avoided in the patient with the GI disease such as the hypermotility or malabsorption syndrome, this dosage form may not be dissolved and may be excreted intact in these conditions. In making the decision to administer the drug during pregnancy, the potential risk to the fetus must be weighed against the potential benefits to the mother.