Isocarboxazid

Isocarboxazid is antidepressant and belongs to monoamino oxidase inhibitors. It forms stable complexes with the enzyme, causing irreversible inactivation.This results in increased stores of norepinephrine, serotinin and dopamine within the neuron and subsequent diffusion of excess neurotransmitter into synaptic space.Isocarboxazid is used to treat depression in patient who are unresponsive to tricyclic antidepressant. Isocarboxazid is also used in the treatment of phobic states.

Brands
Adult Dose
Dose: 0.428 to 0.857 mg/kg
Single Dose: 0.64 (0.6425)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Isocarboxazid also known as Marplon. . It is of Synthetic origin and belongs to Hydrazine. It belongs to Psychotherapeutic Drugs and Anxiolytics pharmacological group.The Molecular Weight of Isocarboxazid is 231.30. Its pKa is 10.4.
Contraindications
Isocarboxazid is contraindicated in conditions like Phaeochromocytoma,Cardiovascular disease,Cerebrovascular disease.
Effects
The severe or irreversible adverse effects of Isocarboxazid, which give rise to further complications include Hypertensive crises.Isocarboxazid produces potentially life-threatening effects which include Purpura, Granulocytopenia. which are responsible for the discontinuation of Isocarboxazid therapy.The signs and symptoms that are produced after the acute overdosage of Isocarboxazid include Tachycardia, Convulsions, Coma, Respiratory depression, Pyrexia, Ataxia, Dizziness, Irritability, Mental confusion.The symptomatic adverse reactions produced by Isocarboxazid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Constipation, Dry mouth, Blurred vision, Peripheral edema, Edema, Orthostatic hypotension, Slow micturition, Postural dizziness, Dry mouth, Oedema, dizziness, Weakness.
Indications
Isocarboxazid is primarily indicated in conditions like Anxiety, Depression, Narcolepsy, Obsessive-compulsive disorders, Panic disorders, Phobias.
Interactions
Isocarboxazid is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAtomoxetine HClSever reactions are possible in this combination.Clomipramine (HCl)EphedrineFenfluramine (HCl)LevodopaMethylphenidate (HCl)NaphazolineConcurrent use may result in interaction. Dosage adjustment or special monitoring during concurrent use is necessary.OxypertineTheoretical potential for OXYPERTINE increasing the CNS STIMULANT effect of ISOCARBOXAZID. PhenylalaninePhenylalanine supplementation may cause a severe increase in blood pressure in people taking Isocarboxazid.Pirbuterol (Acetate)Concurrent use may potentiate the action of pirbuterol on the vascular system.Pirbuterol should be administered with extreme caution to patients being treated with Isocarboxazid.Potassium GuaiacolsulphonatePotassium Guaiacolsulphonate should not be used with or within 14 days of taking Isocarboxazid.PropylhexidrinePotential for enhanced sympathomimetic effects. Use concomitantly with caution.Pseudoephedrine (HCl)SumatriptanIsocarboxazid increases the plasma concentration of sumatriptan by inhibiting their metabolic clearence result in increased risk of vasospastic reactions, including coronory arter yvasospasm, peripheral vascular ischemia and clonic ischemia.MajorThis combination is considered contraindicated. There should be gap of at least 14 days between stopping the isocarboxazid and initiation of sumatriptan.Tetrahydrozoline (HCl)Concurrent use may increase the hypertensive effect.TryptophanVortioxetine increase toxicity of vortioxetinenever use combination These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 15°C. Protect from Sunlight and Moisture.
Warnings
Take adequate precautions when treating epileptic patients. Isocarboxazid should be used with caution in patients with impaired renal (kidney) function and hyperthyroidism. Perform periodic liver function tests, discontinue use at the first sign of hepatic (liver) dysfunction or jaundice.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.