Iopanoic Acid

Iopanoic Acid is iodinated radiographic contrast medium that after oral administration is absorbed from the deudenum, conjugated with glucoronic acid in the liver and secreted in bile. Iopanoic Acid is used as a radiopaque medium in cholecystography and for oral cholangiograghy.


Brands
Adult Dose
Dose: 42.857 mg/kg
Single Dose: 43 (42.857)
Frequency: As recommended.
Route: PO
Instructions: Once,as required
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Iodinated Organic Compounds. It belongs to Radiopaque Agents pharmacological group on the basis of mechanism of action and also classified in Diagnostic Aids pharmacological group.The Molecular Weight of Iopanoic Acid is 571.00. Its pKa is 4.8.
Contraindications
Iopanoic Acid is contraindicated in conditions like Cardiovascular disease,Malabsorption.
Effects
The severe or irreversible adverse effects of Iopanoic Acid, which give rise to further complications include Thrombocytopenia, Renal impairment, Thyrotoxicosis, Urate nephropathy, Hepatic impairment.Iopanoic Acid produces potentially life-threatening effects which include Anaphylactoid reactions, Coronary insufficiency, Cardiovascular collapse. which are responsible for the discontinuation of Iopanoic Acid therapy.The signs and symptoms that are produced after the acute overdosage of Iopanoic Acid include Diarrhea, Nausea & vomiting.The symptomatic adverse reactions produced by Iopanoic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Diarrhea, Abdominal pain, Rashes, Urticaria, Pruritus, Dysuria, Cramps, Nausea and vomiting, Heart burn, Hypersensitivity reactions, Sore throat, dizziness.
Indications
Iopanoic Acid is primarily indicated in conditions like Cholecystography, Epilepsy (monotherapy), Radiological contrast agent, Vestibular disorders, and can also be given in adjunctive therapy as an alternative drug of choice in Hyperthyroidism.
Interactions
No data regarding the interactions of Iopanoic Acid was found.
Interfrence
Thyroid Function Test False +ver result of Sulphosalicylic acid test Pisano Test Serum Urate Measurement Increases Sulphobromophthaline retention Increases Serum Bilirubin
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store at room temperature. Protect from Sunlight.
Warnings
Avoid use of iopanoic acid in patients with severe renal (kidney) or hepatic (liver) disease. Dose higher than 3gm should not be given to patients with renal impairment. Avoid use in presence of acute gastro-intestinal disease, as it may impair the absorption. It should be used with caution in patients with history of hypersensitivity to iodine, or other contrast media, hyperthyroidism, hyperuricaemia.
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