Iodine

Iodine and Iodine releasing agents are widely used as topical broad spectrm antiseptics and as disinfectant and sanitizers. Elemental Iodine was discovered in 1811 and is ablack blue material. Elemental Iodine is highly irritant and corrosive but formulation as an iodophor greatly reduces these unwanted adveres effects. In body Iodine is used in the production of thyroid hormone. When the gland is overactive Iodine is given orally to suppress thyroid function prior to surgical removal of thyroid tissue


Adult Dose
Dose: 0.086 mg/ kg
Single Dose: 0.086 (0.086)
Frequency: 8 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Dose: 0.1 to 0 ml
Single Dose: 0.05 (0.05)
Frequency: As recommended.
Route:
Instructions:
Characteristics
Iodine Compounds, Iodine Compounds are the derivatives of Iodine. It is of Natural origin and belongs to Iodide. It belongs to Minerals and Electrolytes pharmacological group on the basis of mechanism of action and also classified in Antiseptics and Germicides pharmacological group.The Molecular Weight of Iodine is 166.00. Its pKa is Completely Ionized.
Contraindications
'Iodine is contraindicated in conditions like Asthma,Hyperkalaemia,Acne vulgaris,Tuberculosis,Goiter,Hypersensitivity,Bronchitis,Vasculitis,Thomsen''s disease.'
Effects
The severe or irreversible adverse effects of Iodine, which give rise to further complications include Eosinophilia, Eosinophilia, Hypothyroidism, Goitre, Goitre.Iodine produces potentially life-threatening effects which include Neutropenia. which are responsible for the discontinuation of Iodine therapy.The signs and symptoms that are produced after the acute overdosage of Iodine include Vomiting, Diarrhea, Coma, Fever, Delirium, Renal failure, Abdominal pain, Ventricular arrhythmias, Metallic taste, Lactic acidosis.The symptomatic adverse reactions produced by Iodine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Skin rashes, Urticaria, Arthralgia, Sneezing, Salivation, Conjunctivitis, Bronchitis, Enlargement of salivary gland, Vasculitis, Coryza, Iodine toxicity, Skin rashes.
Indications
Iodine is primarily indicated in conditions like Hyperthyroid crisis, Hyperthyroidism, Sporotrichosis, Thyroid involution induction, Thyrotoxicosis, and can also be given in adjunctive therapy as an alternative drug of choice in Thyroidectomy.
Interactions
Iodine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmiodarone (HCl)Di-IodohydroxyquinolineLithiumSulphur These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Thyroid Function Test by supressing radio-iodine uptake from thyroid gland.
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Soln Store in a well closed container, Between 15°C-25°C.
Warnings
Observed patients closely for acute iodide toxicity, if symptoms appear discontinue the therapy. It should be used with caution in patient with hyperthyroidism, cardiac disease or renal (kidney) impairment. Prolong use during pregnancy is not advised.
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