Indapamide

Indapamide is antihypertensive agent. It was synthesized in 1969. Indapamide is the first of a new class of diuretic or antihypertensives, the indolines. It increases the urination and reduces the amount of water and sodium retained by the body. its diuretic effects is similar to that induced by thiazides. Chemically Indapamide is identified as 3-(aminosulfonyl) -4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-benzamide hemihydrate. Indapamide is a 2-methyl indoline derivative of 4-chloro-3-sulfamoyl benzoyl benzamide and differ from the classic Thiazides in lacking a benzothiadiazine hetrocycle and in contaning only one sulfamoyl group.

Brands
INDURIN NATRILIX NATRILIX SIZAMIDE BAPLOW BI PRETERAX PRETERAX COVERSYL PLUS HYPOMIDE HYPOMIDE HARTACE PLUS
Adult Dose
Dose: 2.5 mg
Single Dose: 2.5 (2.5)
Frequency: As recommended.
Route: PO
Instructions: Once as Single Dose in Morning
Neonatal
Dose: Not use in neonates
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Sulphonamide. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.The Molecular Weight of Indapamide is 365.80. Its pKa is 8.3.
Contraindications
Indapamide is contraindicated in conditions like Renal failure,Hepatic failure,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Indapamide, which give rise to further complications include Hypokalemia, Hypercalcemia, Increased BUN (blood urea nitrates), Hyperuricemia, Hypoglycemia, Flaccid paralysis.Indapamide produces potentially life-threatening effects which include Coma, Cardiac Arrest, Cardiac arrest. which are responsible for the discontinuation of Indapamide therapy.The signs and symptoms that are produced after the acute overdosage of Indapamide include Hypokalemia, Hyperuricemia, Muscle fatigue, Weakness, Acute gout.The symptomatic adverse reactions produced by Indapamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Fever, Blurred vision, Skin rash, Agitation, Lassitude, Bleeding, dizziness.
Indications
Indapamide is primarily indicated in conditions like Essential hypertension, Hypertension, Oedema in congestive heart failure, Oedema in pregnancy.
Interactions
Indapamide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementVORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased level of Blood urea nitrogen (BUN) concentrationsIncreased in serum creatininElectrolytes distabance
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Use indapamide, with caution in patients with history of heart rhythm problems, diabetes, gout, kidney, thyroid, parathyroid or liver disease, systemic Lupus erythematosus (SLE) or an allergy to sulfa drugs. Indapamide should not be used during pregnancy or lactation. It should be used with caution in patients with high blood pressure. Electrolyte imbalance should be corrected before the administration of indapamide. Elderly Should take low dose.
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