Imipenem

Imipenem is a β lactam antibiotic derived from thienamycin. It has a wide spectrum with good activity against many gram negative, gram positive organism and anaerobes. Imipenem is given in combination with cilastatin. Antibiotics require constant drug level in body for therapeutic effect. This is attained by taking the medicine at regular interval of time throughout the day and night as prescribed. Imipenem is important to take the drug for the full time period as prescribed. If you stop the therapy it may result in ineffective treatment.

Brands
TIENAM PREPENEM NUPENAM CILAPEN CILAPEN EURONEM STANEM CILAPENEM
Adult Dose
Dose: 500 to 750 mg
Single Dose: 620 (625)
Frequency: 12 hourly
Route: IM
Instructions: In combination with Cilastatin.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 15 to 25 mg/kg
Single Dose: 20 (20)
Frequency: 6 hourly
Route: IV Infusion
Instructions: Total dose should not exceed 2g.
Characteristics
Imipenem also known as Imipemide. . It is of Synthetic origin and belongs to Beta Lactam. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Imipenem is 317.40. It is weakly acidic drug and Its pKa is 3.2, 9.9.
Contraindications
Imipenem is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Imipenem, which give rise to further complications include Thrombocytopenia, Seizures, Renal impairment, Leukopenia.Imipenem produces potentially life-threatening effects which include Pseudomembranous colitis. which are responsible for the discontinuation of Imipenem therapy.The signs and symptoms that are produced after the acute overdosage of Imipenem include Seizures.The symptomatic adverse reactions produced by Imipenem are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vomiting, Diarrhea, Fever, Skin rashes, Urticaria, Pain, Allergic reactions, Glossitis, Hypersalivation, Eosinophilia, Anaphylaxis, Tooth and tongue discoloration, Skin rashes, dizziness.
Indications
Imipenem is primarily indicated in conditions like Abdominal sepsis, Advanced prostate cancer, Biliary tract infections, Bone and joint infection, Brain abscesses, Cellulitis, Diabetic foot ulcer, Endocarditis, Gastric acid reduction during general anaesthesia, Gynecological infections, Lower respiratory tract infections, Obstetric infections, Peritonitis, Pneumonia, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, Surgical anaesthesia, Surgical prophylaxis, UTI.
Interactions
No data regarding the interactions of Imipenem was found.
Interfrence
False +ve reaction for glucose in the urine using Benedicts soln, Fehling soln & Clinitest tablets.+ve Coomb`s tests
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C.
Warnings
Imipenem should be used with caution in patients have allergy to penicillin, cephalosporins. It should be used with caution in patients with history of seizure, kidney, liver or gastrointestinal diseases, asthma or diabetes. It should be used with caution if secondary infection occurs.It should be given with caution to pateints with renal impairment and the dore reduced approtricately. Particular care is neursary in pateints with CNS disorders such as epilepsy.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.