Iloprost

Iloprost is a vasodialator (expands the blood vessels) and platelet aggregation inhibitor.Iloprost is carbacyclin analog of prostaglandin I-2 in which the enolether oxygen of prostaglandin is replaced by a methylene group and the lower side chain is further modified in order to enhance the biological potency as well as the metabolic stability of the chemical. its metabolic half life is longer than that of prostaglandin I-2. Iloprost is effective in the treatment of peripheral vascular disease. There are no combination products that contain this drug Iloprost is a synthetic analogue of prostacylin.

Brands
Adult Dose
Dose: 0.5 to 2 ng/kg.min
Single Dose: 1.2 (1.25)
Frequency: 24 hourly
Route: IV Inf
Instructions: For 6 Hours
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Carbacyclin. It belongs to Prostaglandin pharmacological group.The Molecular Weight of Iloprost is 360.00. Its pKa is 4.7.
Contraindications
Iloprost is contraindicated in conditions like Peptic ulcer,Trauma,Intracranial hemorrhage.
Effects
The severe or irreversible adverse effects of Iloprost, which give rise to further complications include Hypotension, Hypotension, Vasodilation, Vasovagal attacks, Chest pain.The signs and symptoms that are produced after the acute overdosage of Iloprost include Hypotension, Nausea & vomiting, Syncope, Facial flushing.The symptomatic adverse reactions produced by Iloprost are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Nausea, Vomiting, Diarrhea, Malaise, Cough, Bronchospasm, dizziness, Obstructive Arterial disease, Aching in the affective Limb.
Indications
'Iloprost is primarily indicated in conditions like Buerger''s disease, Peripheral arterial occlusive disease, Pulmonary hypertension, Raynaud''s phenomenon.'
Interactions
No data regarding the interactions of Iloprost was found.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
IV inf Store at room temperature.
Warnings
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