Ifosfamide

Ifosfamide is anticancer drug, also called as antineoplastic agent. Ifosfamide is used in the treatment of different cancers to slow or stop abnormally growing cells. Ifosfamide is used in combination with different anticancer drugs in the treatment of cancers to obtain best therapeutic effects and to reduce toxicity or side effects. Ifosfamide is an alkylating agent with properties similar to those of cyclophosphamide.

Brands
IFOSFAMIN IFOSFAMIN HOLOXAN HOLOXAN HOLOXAN FOSFAMIDE IFOS IFOS
Adult Dose
Dose: 5 to 8 g/ sq.meter
Single Dose: 6.5 (6.5)
Frequency: As recommended.
Route: IV
Instructions: 3-4 times in a week
Neonatal
Paedriatic
Dose: 1200 to 1800 mg/sq.meter
Single Dose: 1500 (1500)
Frequency: 24 hourly
Route: Intra Venous
Instructions: For 5 Days, every 21-28 day cycle
Characteristics
. It is of Synthetic origin and belongs to Oxazaphosphorine. It belongs to Alkylating Agents pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Alkylating Agent pharmacological group.The Molecular Weight of Ifosfamide is 261.10.
Contraindications
Ifosfamide is contraindicated in conditions like UTI,Bone marrow aplasia,Impaired hepatic function,Myelosuppression,Impaired renal function,Hypersensitivity,Prior urothelial toxicity.
Effects
The severe or irreversible adverse effects of Ifosfamide, which give rise to further complications include Nephrotoxicity, Neutropenia, Seizures, Hematuria, Renal toxicity, Hypophosphatemic rickets, Leukopenia, Renal tubular necrosis.Ifosfamide produces potentially life-threatening effects which include Hypokalemia, Encephalopathy, CNS toxicity, Hypokalemia, Logomania, Palilalia, Perseveration, Disorientation. which are responsible for the discontinuation of Ifosfamide therapy.The signs and symptoms that are produced after the acute overdosage of Ifosfamide include Myelosuppression, Hemorrhagic cystitis.The symptomatic adverse reactions produced by Ifosfamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Ataxia, Nausea, Vomiting, Alopecia, Restlessness, Confusion, Dysuria, Azotemia, Confusion, Alopecia, Ataxia.
Indications
'Ifosfamide is primarily indicated in conditions like Breast cancer, Cervical carcinoma, Chronic lymphocytic leukaemia, Lung cancer, Ovarian cancer, Soft tissue sarcoma, Testicular cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Carcinoma of pancrease, Head and neck cancer, Malignant lymphoma, Non-hodgkin''s lymphoma, Non-hodgkin''s lymphoma, Osteosarcoma, Pediatric solid tumors.'
Interactions
Ifosfamide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCisplatinIfofasfamide may potentiate toxicity produced by cisplatin.ModerateSerial audiograms is advised.VORICONAZOLEVoriconazole may increase the serum concentration of ifosfamide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of ifosfamide if voriconazole is initiated, discontinued or dose changed.Warfarin (Na)Ifosfamide may enhance the anticoagulant effect of Warfarin. ModerateMonitor for increased INR/effects of Warfarin when ifosfamide is initiated/dose increased, and decreased INR/effects when ifosfamide is discontinued/dose decreased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
False positive test for urinary ketones by Rotheras Test, Multistix reagent strip methodMay occur in pateints receiving mesn
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 30°C.
Warnings
Ifosfamide has little therapeutic index and therapeutic doses are likely to cause toxicity.This medication must not be used during pregnancy or lactation. Use with caution in patients with pre-existing kidney disease or any blood disorder. IM injection should not be administered during ifosfamide therapy. Dehydration should be corrected prior to therapy with ifosfamide.The duration of exposure of the drug to the bladder wall should be minimized.
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