Hydroxyurea

Hydroxyurea is anticancer drug, also called antineoplastic agent. Hydroxyurea is an analog of urea. Hydroxyurea is effective in the treatment of different cancers to slow or stop the abnormally growing cells. Hydroxyurea is used in combination with different anticancer drugs to obtain best therapeutic effects and to reduce toxicity or side effects. Hydroxyurea is administered orally.

Brands
HYDRINE HYDREA HYDROUREA URO-Z HYDRA
Adult Dose
Dose: 20 to 30 mg/kg/day
Single Dose: 25 (25)
Frequency: As recommended.
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
Hydroxyurea also known as Hydroxycarbamide. . It is of Synthetic origin and belongs to Amino Ketone. It belongs to Ribonucleoside diphosphate reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agnet, Antimetabolite pharmacological group.The Molecular Weight of Hydroxyurea is 76.06.
Contraindications
Hydroxyurea is contraindicated in conditions like Anaemia,Thrombocytopenia,Leukopenia.
Effects
The severe or irreversible adverse effects of Hydroxyurea, which give rise to further complications include Fever, Hyperuricemia, Eelvated hepatic enzymes, Malaise, Dysuria, Impaired renal tubular function, Increased blood urea nitrogen, Increased creatinine, Chills.Hydroxyurea produces potentially life-threatening effects which include Anemia, Bone marrow suppression, Thrombocytopenia, Leucopenia, Edema, Anemia. which are responsible for the discontinuation of Hydroxyurea therapy.The symptomatic adverse reactions produced by Hydroxyurea are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Alopecia, Anorexia, Diarrhea, Constipation, Rashes, Erythema, Hallucination, StomatitisX, Disorientation, Nausea and vomiting, Convulsions, Melena, Alopecia, dizziness.
Indications
Hydroxyurea is primarily indicated in conditions like Acute leukemia, Beta thalassaemia, Brain tumors, Chronic myeloid leukaemia, Myeloproliferative disorders, Polycythemia vera, Sickle cell anaemia, Solid tumor, and can also be given in adjunctive therapy as an alternative drug of choice in Psoriasis, Viral infection.
Interactions
No data regarding the interactions of Hydroxyurea was found.
Interfrence
Monitoring of hematologic profile
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, at room temperature, Below 40°C.
Warnings
Hydroxyurea is not recommended for use in pregnant or nursing women. Elderly patients may be more sensitive to the effects of this drug and may require a lower dosing. Ues with caution in renal impairment pateints.
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